1uw1
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | 1UW1 is a | + | 1UW1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with ZN and ADP as [http://en.wikipedia.org/wiki/ligands ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UW1 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: nucleotide binding protein]] | [[Category: nucleotide binding protein]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 12:55:41 2007'' |
Revision as of 10:50, 5 November 2007
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A NOVEL ADP- AND ZINC-BINDING FOLD FROM FUNCTION-DIRECTED IN VITRO EVOLUTION
Overview
A great challenge to biologists is to create proteins with novel folds and, tailored functions. As an alternative to de novo protein design, we, investigated the structure of a randomly generated protein targeted to, bind ATP. The crystal structure reveals a novel alpha/beta fold bound to, its ligand, representing both the first protein structure derived from in, vitro evolution and the first nucleotide-binding protein stabilized by a, zinc ion.
About this Structure
1UW1 is a Single protein structure of sequence from [1] with ZN and ADP as ligands. Structure known Active Site: AC1. Full crystallographic information is available from OCA.
Reference
A novel ADP- and zinc-binding fold from function-directed in vitro evolution., Lo Surdo P, Walsh MA, Sollazzo M, Nat Struct Mol Biol. 2004 Apr;11(4):382-3. Epub 2004 Mar 14. PMID:15024384 [[Category: ]]
Page seeded by OCA on Mon Nov 5 12:55:41 2007
