CD3
From Proteopedia
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(New page: <StructureSection load='1sy6' size='350' side='right' caption='Structure of human CD2 extracellular domain complex with antibody (PDB entry 1sy6)' scene=''> '''CD3''' (or '''Cluste...) |
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| - | <StructureSection load='1sy6' size='350' side='right' caption='Structure of human CD2 extracellular domain complex with antibody (PDB entry [[1sy6]])' scene=''> | + | |
'''CD3''' (or '''Cluster of Differentiation 3''') is a T-cell co-receptor. The CD3 is composed of γ, δ and two ε chains. These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes. CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ. The intracellular domain of CD3 contains a single immunorecetor tyrosine-based activation motif (ITAM). Drugs which bind to CD3 are tested as immunorepressants. | '''CD3''' (or '''Cluster of Differentiation 3''') is a T-cell co-receptor. The CD3 is composed of γ, δ and two ε chains. These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes. CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ. The intracellular domain of CD3 contains a single immunorecetor tyrosine-based activation motif (ITAM). Drugs which bind to CD3 are tested as immunorepressants. | ||
Revision as of 10:59, 27 June 2013
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