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4k5y

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4k5y| PDB=4k5y | SCENE= }}
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===Crystal structure of human corticotropin-releasing factor receptor 1 (CRF1R) in complex with the antagonist CP-376395===
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The entry 4k5y is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/CRFR1_HUMAN CRFR1_HUMAN]] Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.<ref>PMID:18801728</ref>
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Authors: Hollenstein, K., Kean, J., Bortolato, A., Cheng, R.K.Y., Dore, A.S., Jazayeri, A., Cooke, R.M., Weir, M., Marshall, F.H.
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==About this Structure==
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[[4k5y]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K5Y OCA].
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Description: Crystal structure of human corticotropin-releasing factor receptor 1 (CRF1R) in complex with the antagonist CP-376395
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Bortolato, A.]]
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[[Category: Cheng, R K.Y.]]
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[[Category: Cooke, R M.]]
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[[Category: Dore, A S.]]
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[[Category: Hollenstein, K.]]
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[[Category: Jazayeri, A.]]
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[[Category: Kean, J.]]
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[[Category: Marshall, F H.]]
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[[Category: Weir, M.]]
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[[Category: 7tm]]
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[[Category: Family b]]
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[[Category: G-protein]]
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[[Category: Gpcr]]
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[[Category: Membrane]]
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[[Category: Membrane protein]]
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[[Category: Receptor]]
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[[Category: Signalling protein]]

Revision as of 05:04, 18 July 2013

Template:STRUCTURE 4k5y

Contents

Crystal structure of human corticotropin-releasing factor receptor 1 (CRF1R) in complex with the antagonist CP-376395

Function

[CRFR1_HUMAN] Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.[1]

About this Structure

4k5y is a 3 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Pioszak AA, Parker NR, Suino-Powell K, Xu HE. Molecular recognition of corticotropin-releasing factor by its G-protein-coupled receptor CRFR1. J Biol Chem. 2008 Nov 21;283(47):32900-12. Epub 2008 Sep 17. PMID:18801728 doi:10.1074/jbc.M805749200

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