2hwk
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:2hwk.gif|left|200px]] | + | [[Image:2hwk.gif|left|200px]] |
| - | + | ||
| - | '''Crystal Structure of Venezuelan Equine Encephalitis Alphavirus nsP2 Protease Domain''' | + | {{Structure |
| + | |PDB= 2hwk |SIZE=350|CAPTION= <scene name='initialview01'>2hwk</scene>, resolution 2.45Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=FMT:FORMIC ACID'>FMT</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= NS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11036 Venezuelan equine encephalitis virus]) | ||
| + | }} | ||
| + | |||
| + | '''Crystal Structure of Venezuelan Equine Encephalitis Alphavirus nsP2 Protease Domain''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2HWK is a [ | + | 2HWK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Venezuelan_equine_encephalitis_virus Venezuelan equine encephalitis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HWK OCA]. |
==Reference== | ==Reference== | ||
| - | The crystal structure of the Venezuelan equine encephalitis alphavirus nsP2 protease., Russo AT, White MA, Watowich SJ, Structure. 2006 Sep;14(9):1449-58. PMID:[http:// | + | The crystal structure of the Venezuelan equine encephalitis alphavirus nsP2 protease., Russo AT, White MA, Watowich SJ, Structure. 2006 Sep;14(9):1449-58. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16962975 16962975] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Venezuelan equine encephalitis virus]] | [[Category: Venezuelan equine encephalitis virus]] | ||
| Line 21: | Line 30: | ||
[[Category: rossman fold]] | [[Category: rossman fold]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:22:30 2008'' |
Revision as of 15:22, 20 March 2008
| |||||||
| , resolution 2.45Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | NS (Venezuelan equine encephalitis virus) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of Venezuelan Equine Encephalitis Alphavirus nsP2 Protease Domain
Overview
Alphavirus replication and propagation is dependent on the protease activity of the viral nsP2 protein, which cleaves the nsP1234 polyprotein replication complex into functional components. Thus, nsP2 is an attractive target for drug discovery efforts to combat highly pathogenic alphaviruses. Unfortunately, antiviral development has been hampered by a lack of structural information for the nsP2 protease. Here, we report the crystal structure of the nsP2 protease (nsP2pro) from Venezuelan equine encephalitis alphavirus determined at 2.45 A resolution. The protease structure consists of two distinct domains. The nsP2pro N-terminal domain contains the catalytic dyad cysteine and histidine residues organized in a protein fold that differs significantly from any known cysteine protease or protein folds. The nsP2pro C-terminal domain displays structural similarity to S-adenosyl-L-methionine-dependent RNA methyltransferases and provides essential elements that contribute to substrate recognition and may also regulate the structure of the substrate binding cleft.
About this Structure
2HWK is a Single protein structure of sequence from Venezuelan equine encephalitis virus. Full crystallographic information is available from OCA.
Reference
The crystal structure of the Venezuelan equine encephalitis alphavirus nsP2 protease., Russo AT, White MA, Watowich SJ, Structure. 2006 Sep;14(9):1449-58. PMID:16962975
Page seeded by OCA on Thu Mar 20 17:22:30 2008
