4la5

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m (Protected "4la5" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4la5| PDB=4la5 | SCENE= }}
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===Crystal structure of 2-methylisoborneol synthase from Streptomyces coelicolor A3(2)===
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{{ABSTRACT_PUBMED_23844678}}
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The entry 4la5 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/MIBS_STRCO MIBS_STRCO]] Catalyzes the cyclization of 2-methylgeranyl diphosphate (2-MeGPP) to 2-methylisoborneol (2-MIB), which likely involves the intermediacy of 2-methyllinalyl diphosphate. Is also able to catalyze the cyclization of geranyl diphosphate (GPP), albeit with much lower efficiency, leading to the formation of a complex mixture of cyclic monoterpenes, consisting of alpha-pinene (6%), beta-pinene (23%), limonene (32%), gamma-terpinene (29%), and delta-terpinene (10%).
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Authors: Koksal, M., Christianson, D.W.
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==About this Structure==
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[[4la5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor_a3(2) Streptomyces coelicolor a3(2)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LA5 OCA].
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Description: Crystal structure of 2-methylisoborneol synthase from Streptomyces coelicolor A3(2)
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==Reference==
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<ref group="xtra">PMID:023844678</ref><references group="xtra"/><references/>
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[[Category: 2-methylisoborneol synthase]]
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[[Category: Christianson, D W.]]
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[[Category: Koksal, M.]]
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[[Category: Biosynthesis]]
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[[Category: Isoprenoid synthase fold]]
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[[Category: Lyase]]
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[[Category: Terpenoid biosynthesis]]

Revision as of 05:26, 1 August 2013

Template:STRUCTURE 4la5

Contents

Crystal structure of 2-methylisoborneol synthase from Streptomyces coelicolor A3(2)

Template:ABSTRACT PUBMED 23844678

Function

[MIBS_STRCO] Catalyzes the cyclization of 2-methylgeranyl diphosphate (2-MeGPP) to 2-methylisoborneol (2-MIB), which likely involves the intermediacy of 2-methyllinalyl diphosphate. Is also able to catalyze the cyclization of geranyl diphosphate (GPP), albeit with much lower efficiency, leading to the formation of a complex mixture of cyclic monoterpenes, consisting of alpha-pinene (6%), beta-pinene (23%), limonene (32%), gamma-terpinene (29%), and delta-terpinene (10%).

About this Structure

4la5 is a 1 chain structure with sequence from Streptomyces coelicolor a3(2). Full crystallographic information is available from OCA.

Reference

  • Koksal M, Chou WK, Cane DE, Christianson DW. Unexpected Reactivity of 2-Fluorolinalyl Diphosphate in the Active Site of Crystalline 2-Methylisoborneol Synthase. Biochemistry. 2013 Jul 22. PMID:23844678 doi:10.1021/bi400797c

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