4jbj
From Proteopedia
(Difference between revisions)
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| - | + | ==Structural mimicry for functional antagonism== | |
| - | === | + | <StructureSection load='4jbj' size='340' side='right' caption='[[4jbj]], [[Resolution|resolution]] 2.69Å' scene=''> |
| - | + | == Structural highlights == | |
| - | ==Function== | + | <table><tr><td colspan='2'>[[4jbj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JBJ FirstGlance]. <br> |
| + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jbk|4jbk]], [[4jbm|4jbm]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ifi202a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jbj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jbj RCSB], [http://www.ebi.ac.uk/pdbsum/4jbj PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
[[http://www.uniprot.org/uniprot/IFI2_MOUSE IFI2_MOUSE]] Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Has anti-apoptotic effects due to inhibition of the transcriptional activity of p53. Binds dsDNA in the cytosol. Is involved in innate immune response and has anti-inflammatory activity. Inhibits caspase activation in response to cytosolic DNA and may inhibit the activation of the AIM2 inflammasome, probably via association with AIM2.<ref>PMID:16670293</ref> <ref>PMID:19131592</ref> | [[http://www.uniprot.org/uniprot/IFI2_MOUSE IFI2_MOUSE]] Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Has anti-apoptotic effects due to inhibition of the transcriptional activity of p53. Binds dsDNA in the cytosol. Is involved in innate immune response and has anti-inflammatory activity. Inhibits caspase activation in response to cytosolic DNA and may inhibit the activation of the AIM2 inflammasome, probably via association with AIM2.<ref>PMID:16670293</ref> <ref>PMID:19131592</ref> | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
| - | + | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Cheng, G | + | [[Category: Cheng, G]] |
| - | [[Category: Ding, W | + | [[Category: Ding, W]] |
| - | [[Category: Hung, L W | + | [[Category: Hung, L W]] |
| - | [[Category: Liu, Z J | + | [[Category: Liu, Z J]] |
| - | [[Category: Ma, F | + | [[Category: Ma, F]] |
| - | [[Category: Ni, X | + | [[Category: Ni, X]] |
| - | [[Category: Ru, H | + | [[Category: Ru, H]] |
| - | [[Category: Shaw, N | + | [[Category: Shaw, N]] |
| - | [[Category: Zhao, L | + | [[Category: Zhao, L]] |
[[Category: Dna binding protein]] | [[Category: Dna binding protein]] | ||
[[Category: Ds dna]] | [[Category: Ds dna]] | ||
[[Category: Ob fold]] | [[Category: Ob fold]] | ||
Revision as of 22:25, 24 December 2014
Structural mimicry for functional antagonism
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Categories: Mus musculus | Cheng, G | Ding, W | Hung, L W | Liu, Z J | Ma, F | Ni, X | Ru, H | Shaw, N | Zhao, L | Dna binding protein | Ds dna | Ob fold
