4jvu
From Proteopedia
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| - | + | ==IgM C2-domain from mouse== | |
| - | === | + | <StructureSection load='4jvu' size='340' side='right' caption='[[4jvu]], [[Resolution|resolution]] 1.30Å' scene=''> |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4jvu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JVU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JVU FirstGlance]. <br> | ||
| + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1o0v|1o0v]], [[4jvw|4jvw]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Igh-6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jvu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jvu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jvu RCSB], [http://www.ebi.ac.uk/pdbsum/4jvu PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | IgM is the first antibody produced during the humoral immune response. Despite its fundamental role in the immune system, IgM is structurally only poorly described. In this work we used X-ray crystallography and NMR spectroscopy to determine the atomic structures of the constant IgM Fc domains (Cmicro2, Cmicro3, and Cmicro4) and to address their roles in IgM oligomerization. Although the isolated domains share the typical Ig fold, they differ substantially in dimerization properties and quaternary contacts. Unexpectedly, the Cmicro4 domain and its C-terminal tail piece are responsible and sufficient for the specific polymerization of Cmicro4 dimers into covalently linked hexamers of dimers. Based on small angle X-ray scattering data, we present a model of the ring-shaped Cmicro4 structure, which reveals the principles of IgM oligomerization. | ||
| - | + | High-resolution structures of the IgM Fc domains reveal principles of its hexamer formation.,Muller R, Grawert MA, Kern T, Madl T, Peschek J, Sattler M, Groll M, Buchner J Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10183-8. doi:, 10.1073/pnas.1300547110. Epub 2013 Jun 3. PMID:23733956<ref>PMID:23733956</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Buchner, J | + | [[Category: Buchner, J]] |
| - | [[Category: Graewert, A M | + | [[Category: Graewert, A M]] |
| - | [[Category: Groll, M | + | [[Category: Groll, M]] |
| - | [[Category: Kern, T | + | [[Category: Kern, T]] |
| - | [[Category: Madl, T | + | [[Category: Madl, T]] |
| - | [[Category: Mueller, R | + | [[Category: Mueller, R]] |
| - | [[Category: Peschek, J | + | [[Category: Peschek, J]] |
| - | [[Category: Sattler, M | + | [[Category: Sattler, M]] |
[[Category: Antibody]] | [[Category: Antibody]] | ||
[[Category: Immunoglobulin fold]] | [[Category: Immunoglobulin fold]] | ||
Revision as of 14:26, 4 January 2015
IgM C2-domain from mouse
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