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2i39

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[[Image:2i39.gif|left|200px]]<br /><applet load="2i39" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2i39.gif|left|200px]]
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caption="2i39, resolution 2.20&Aring;" />
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'''Crystal structure of Vaccinia virus N1L protein'''<br />
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{{Structure
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|PDB= 2i39 |SIZE=350|CAPTION= <scene name='initialview01'>2i39</scene>, resolution 2.20&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>
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|ACTIVITY=
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|GENE= N1L (VACWR028) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10245 Vaccinia virus])
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}}
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'''Crystal structure of Vaccinia virus N1L protein'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2I39 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus] with <scene name='pdbligand=MPD:'>MPD</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I39 OCA].
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2I39 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I39 OCA].
==Reference==
==Reference==
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Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein., Aoyagi M, Zhai D, Jin C, Aleshin AE, Stec B, Reed JC, Liddington RC, Protein Sci. 2007 Jan;16(1):118-24. Epub 2006 Nov 22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17123957 17123957]
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Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein., Aoyagi M, Zhai D, Jin C, Aleshin AE, Stec B, Reed JC, Liddington RC, Protein Sci. 2007 Jan;16(1):118-24. Epub 2006 Nov 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17123957 17123957]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Vaccinia virus]]
[[Category: Vaccinia virus]]
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[[Category: all alpha]]
[[Category: all alpha]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:48:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:24:52 2008''

Revision as of 15:24, 20 March 2008

Image:2i39.gif


PDB ID 2i39

Drag the structure with the mouse to rotate
, resolution 2.20Å
Ligands:
Gene: N1L (VACWR028) (Vaccinia virus)
Coordinates: save as pdb, mmCIF, xml



Crystal structure of Vaccinia virus N1L protein


Overview

Poxviruses encode immuno-modulatory proteins capable of subverting host defenses. The poxvirus vaccinia expresses a small 14-kDa protein, N1L, that is critical for virulence. We report the crystal structure of N1L, which reveals an unexpected but striking resemblance to host apoptotic regulators of the B cell lymphoma-2 (Bcl-2) family. Although N1L lacks detectable Bcl-2 homology (BH) motifs at the sequence level, we show that N1L binds with high affinity to the BH3 peptides of pro-apoptotic Bcl-2 family proteins in vitro, consistent with a role for N1L in modulating host antiviral defenses.

About this Structure

2I39 is a Single protein structure of sequence from Vaccinia virus. Full crystallographic information is available from OCA.

Reference

Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein., Aoyagi M, Zhai D, Jin C, Aleshin AE, Stec B, Reed JC, Liddington RC, Protein Sci. 2007 Jan;16(1):118-24. Epub 2006 Nov 22. PMID:17123957

Page seeded by OCA on Thu Mar 20 17:24:52 2008

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