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4fqw

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4fqw| PDB=4fqw | SCENE= }}
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===Crystal Structure of AAAA+UDP+Gal at pH 5.0 with MPD as the cryoprotectant===
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{{ABSTRACT_PUBMED_24265507}}
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The entry 4fqw is ON HOLD until Dec 25 2014
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==Function==
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[[http://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN]] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
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Authors: Johal, A.R., Alfaro, J.A., Blackler, R.J., Schuman, B., Borisova, S.N., Evans, S.V.
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==About this Structure==
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[[4fqw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQW OCA].
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Description: Crystal Structure of AAAA+UDP+Gal at pH 5.0 with MPD as the cryoprotectant
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==Reference==
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<ref group="xtra">PMID:024265507</ref><references group="xtra"/><references/>
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[[Category: Alfaro, J A.]]
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[[Category: Blackler, R J.]]
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[[Category: Borisova, S N.]]
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[[Category: Evans, S V.]]
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[[Category: Johal, A R.]]
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[[Category: Schuman, B.]]
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[[Category: Abo rossmann fold]]
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[[Category: Blood group antigen]]
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[[Category: Glycoprotein]]
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[[Category: Manganese]]
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[[Category: Metal binding]]
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[[Category: Retaining glycosyltransferase]]
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[[Category: Transferase]]

Revision as of 10:19, 25 December 2013

Template:STRUCTURE 4fqw

Contents

Crystal Structure of AAAA+UDP+Gal at pH 5.0 with MPD as the cryoprotectant

Template:ABSTRACT PUBMED 24265507

Function

[BGAT_HUMAN] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.

About this Structure

4fqw is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Johal AR, Blackler RJ, Alfaro JA, Schuman B, Borisova S, Evans SV. pH-induced conformational changes in human ABO(H) blood group glycosyltransferases confirm the importance of electrostatic interactions in formation of the semi-closed state. Glycobiology. 2013 Nov 20. PMID:24265507 doi:http://dx.doi.org/10.1093/glycob/cwt098

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OCA

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