4iop

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'''Unreleased structure'''
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{{STRUCTURE_4iop| PDB=4iop | SCENE= }}
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===Crystal structure of NKp65 bound to its ligand KACL===
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{{ABSTRACT_PUBMED_23803857}}
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The entry 4iop is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/CLC2A_HUMAN CLC2A_HUMAN]] Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti-apoptotic proteins. May modulate the capacity of T-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity.<ref>PMID:18550855</ref> <ref>PMID:20194751</ref> [[http://www.uniprot.org/uniprot/KLRF2_HUMAN KLRF2_HUMAN]] C-type lectin-like receptor involved in natural killer cell mediated cytotoxicity and cytokine secretion in keratinocytes via its interaction with CLEC2A.
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Authors: Li, Y.
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==About this Structure==
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[[4iop]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IOP OCA].
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Description: Crystal structure of NKp65 bound to its ligand KACL
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==Reference==
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<ref group="xtra">PMID:023803857</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Li, Y.]]
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[[Category: Immune system]]
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[[Category: Nk cell receptor]]
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[[Category: Receptor-ligand complex]]

Revision as of 04:58, 18 July 2013

Template:STRUCTURE 4iop

Contents

Crystal structure of NKp65 bound to its ligand KACL

Template:ABSTRACT PUBMED 23803857

Function

[CLC2A_HUMAN] Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti-apoptotic proteins. May modulate the capacity of T-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity.[1] [2] [KLRF2_HUMAN] C-type lectin-like receptor involved in natural killer cell mediated cytotoxicity and cytokine secretion in keratinocytes via its interaction with CLEC2A.

About this Structure

4iop is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Li Y, Wang Q, Chen S, Brown PH, Mariuzza RA. Structure of NKp65 bound to its keratinocyte ligand reveals basis for genetically linked recognition in natural killer gene complex. Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11505-10. doi:, 10.1073/pnas.1303300110. Epub 2013 Jun 26. PMID:23803857 doi:10.1073/pnas.1303300110
  1. ↑ Huarte E, Cubillos-Ruiz JR, Nesbeth YC, Scarlett UK, Martinez DG, Engle XA, Rigby WF, Pioli PA, Guyre PM, Conejo-Garcia JR. PILAR is a novel modulator of human T-cell expansion. Blood. 2008 Aug 15;112(4):1259-68. doi: 10.1182/blood-2007-12-130773. Epub 2008, Jun 12. PMID:18550855 doi:10.1182/blood-2007-12-130773
  2. ↑ Spreu J, Kuttruff S, Stejfova V, Dennehy KM, Schittek B, Steinle A. Interaction of C-type lectin-like receptors NKp65 and KACL facilitates dedicated immune recognition of human keratinocytes. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5100-5. doi:, 10.1073/pnas.0913108107. Epub 2010 Mar 1. PMID:20194751 doi:10.1073/pnas.0913108107

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