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4isy

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'''Unreleased structure'''
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{{STRUCTURE_4isy| PDB=4isy | SCENE= }}
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===Crystal structure of IscS from Mycobacterium tuberculosis===
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{{ABSTRACT_PUBMED_24548275}}
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The entry 4isy is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/ISCS_MYCTU ISCS_MYCTU]] Catalyzes the removal of elemental sulfur from cysteine to produce alanine (Probable). Participates in the biosynthesis of metalloclusters by providing the inorganic sulfur required for Fe-S core formation. One acceptor is Whib3, on which this enzyme assembles a 4Fe-4S cluster.
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Authors: Rybniker, J., Pojer, F., Cole, S.T.
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==About this Structure==
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[[4isy]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ISY OCA].
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Description: Crystal structure of IscS from Mycobacterium tuberculosis
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==Reference==
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<ref group="xtra">PMID:024548275</ref><references group="xtra"/><references/>
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[[Category: Cysteine desulfurase]]
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[[Category: Cole, S T.]]
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[[Category: Pojer, F.]]
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[[Category: Rybniker, J.]]
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[[Category: Desulfurase]]
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[[Category: Plp cofactor]]
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[[Category: Transferase]]

Revision as of 18:14, 3 March 2014

Template:STRUCTURE 4isy

Contents

Crystal structure of IscS from Mycobacterium tuberculosis

Template:ABSTRACT PUBMED 24548275

Function

[ISCS_MYCTU] Catalyzes the removal of elemental sulfur from cysteine to produce alanine (Probable). Participates in the biosynthesis of metalloclusters by providing the inorganic sulfur required for Fe-S core formation. One acceptor is Whib3, on which this enzyme assembles a 4Fe-4S cluster.

About this Structure

4isy is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  • Rybniker J, Pojer F, Marienhagen J, Kolly GS, Chen JM, van Gumpel E, Hartmann P, Cole ST. The cysteine desulfurase IscS of Mycobacterium tuberculosis is involved in iron-sulfur cluster biogenesis and oxidative stress defense. Biochem J. 2014 Feb 19. PMID:24548275 doi:http://dx.doi.org/10.1042/BJ20130732

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OCA

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