4ldq

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m (Protected "4ldq" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4ldq| PDB=4ldq | SCENE= }}
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===Crystal Structure of the Mediator of Rho Dependent Invasion===
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{{ABSTRACT_PUBMED_23859498}}
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The entry 4ldq is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/MTNA_HUMAN MTNA_HUMAN]] Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.<ref>PMID:19620624</ref>
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Authors: Sousa, M.C., Templeton, P.D., Metzner, S.I.
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==About this Structure==
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[[4ldq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDQ OCA].
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Description: Crystal Structure of the Mediator of Rho Dependent Invasion
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==Reference==
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<ref group="xtra">PMID:023859498</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: S-methyl-5-thioribose-1-phosphate isomerase]]
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[[Category: Metzner, S I.]]
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[[Category: Sousa, M C.]]
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[[Category: Templeton, P D.]]
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[[Category: Cell invasion]]
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[[Category: Helix bundle]]
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[[Category: Isomerase]]
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[[Category: Rossmann-like fold]]

Revision as of 05:26, 1 August 2013

Template:STRUCTURE 4ldq

Contents

Crystal Structure of the Mediator of Rho Dependent Invasion

Template:ABSTRACT PUBMED 23859498

Function

[MTNA_HUMAN] Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.[1]

About this Structure

4ldq is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Templeton PD, Litman ES, Metzner SI, Ahn NG, Sousa MC. Structure of MRDI Explains its Dual Function as a Metabolic Enzyme and a Mediator of Cell Invasion. Biochemistry. 2013 Jul 16. PMID:23859498 doi:10.1021/bi400556e
  1. ↑ Kabuyama Y, Litman ES, Templeton PD, Metzner SI, Witze ES, Argast GM, Langer SJ, Polvinen K, Shellman Y, Chan D, Shabb JB, Fitzpatrick JE, Resing KA, Sousa MC, Ahn NG. A mediator of Rho-dependent invasion moonlights as a methionine salvage enzyme. Mol Cell Proteomics. 2009 Oct;8(10):2308-20. doi: 10.1074/mcp.M900178-MCP200., Epub 2009 Jul 20. PMID:19620624 doi:10.1074/mcp.M900178-MCP200

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