4ldr

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "4ldr" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4ldr| PDB=4ldr | SCENE= }}
 +
===Structure of the S283Y mutant of MRDI===
 +
{{ABSTRACT_PUBMED_23859498}}
-
The entry 4ldr is ON HOLD
+
==Function==
 +
[[http://www.uniprot.org/uniprot/MTNA_HUMAN MTNA_HUMAN]] Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.<ref>PMID:19620624</ref>
-
Authors: Sousa, M.C., Templeton, P.D., Metzner, S.I.
+
==About this Structure==
 +
[[4ldr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDR OCA].
-
Description: Structure of the S283Y mutant of MRDI
+
==Reference==
 +
<ref group="xtra">PMID:023859498</ref><references group="xtra"/><references/>
 +
[[Category: Homo sapiens]]
 +
[[Category: S-methyl-5-thioribose-1-phosphate isomerase]]
 +
[[Category: Metzner, S I.]]
 +
[[Category: Sousa, M C.]]
 +
[[Category: Templeton, P D.]]
 +
[[Category: Cell invasion]]
 +
[[Category: Helix bundle]]
 +
[[Category: Isomerase]]
 +
[[Category: Rossmann-like fold]]

Revision as of 05:26, 1 August 2013

Template:STRUCTURE 4ldr

Contents

Structure of the S283Y mutant of MRDI

Template:ABSTRACT PUBMED 23859498

Function

[MTNA_HUMAN] Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.[1]

About this Structure

4ldr is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Templeton PD, Litman ES, Metzner SI, Ahn NG, Sousa MC. Structure of MRDI Explains its Dual Function as a Metabolic Enzyme and a Mediator of Cell Invasion. Biochemistry. 2013 Jul 16. PMID:23859498 doi:10.1021/bi400556e
  1. ↑ Kabuyama Y, Litman ES, Templeton PD, Metzner SI, Witze ES, Argast GM, Langer SJ, Polvinen K, Shellman Y, Chan D, Shabb JB, Fitzpatrick JE, Resing KA, Sousa MC, Ahn NG. A mediator of Rho-dependent invasion moonlights as a methionine salvage enzyme. Mol Cell Proteomics. 2009 Oct;8(10):2308-20. doi: 10.1074/mcp.M900178-MCP200., Epub 2009 Jul 20. PMID:19620624 doi:10.1074/mcp.M900178-MCP200

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4ldr"
Personal tools