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2i6e

From Proteopedia

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[[Image:2i6e.gif|left|200px]]<br /><applet load="2i6e" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2i6e.gif|left|200px]]
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caption="2i6e, resolution 2.50&Aring;" />
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'''Crystal structure of protein DR0370 from Deinococcus radiodurans, Pfam DUF178'''<br />
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{{Structure
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|PDB= 2i6e |SIZE=350|CAPTION= <scene name='initialview01'>2i6e</scene>, resolution 2.50&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
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|ACTIVITY=
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|GENE= DR_0370 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1299 Deinococcus radiodurans])
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}}
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'''Crystal structure of protein DR0370 from Deinococcus radiodurans, Pfam DUF178'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2I6E is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I6E OCA].
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2I6E is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I6E OCA].
==Reference==
==Reference==
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X-ray structures of two proteins belonging to Pfam DUF178 revealed unexpected structural similarity to the DUF191 Pfam family., Tyagi R, Burley SK, Swaminathan S, BMC Struct Biol. 2007 Oct 1;7:62. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17908300 17908300]
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X-ray structures of two proteins belonging to Pfam DUF178 revealed unexpected structural similarity to the DUF191 Pfam family., Tyagi R, Burley SK, Swaminathan S, BMC Struct Biol. 2007 Oct 1;7:62. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17908300 17908300]
[[Category: Deinococcus radiodurans]]
[[Category: Deinococcus radiodurans]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: protein structure initiative]]
[[Category: protein structure initiative]]
[[Category: psi-2]]
[[Category: psi-2]]
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[[Category: structural genomics]]
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[[Category: structural genomic]]
[[Category: unknown function]]
[[Category: unknown function]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:49:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:25:58 2008''

Revision as of 15:25, 20 March 2008

Image:2i6e.gif


PDB ID 2i6e

Drag the structure with the mouse to rotate
, resolution 2.50Å
Ligands:
Gene: DR_0370 (Deinococcus radiodurans)
Coordinates: save as pdb, mmCIF, xml



Crystal structure of protein DR0370 from Deinococcus radiodurans, Pfam DUF178


Overview

BACKGROUND: Pfam is a comprehensive collection of protein domains and families, with a range of well-established information including genome annotation. Pfam has two large series of functionally uncharacterized families, known as Domains of Unknown Function (DUFs) and Uncharacterized Protein Families (UPFs). RESULTS: Crystal structures of two proteins from Deinococcus radiodurans and Streptomyces coelicolor belonging to Pfam protein family DUF178 (ID: PF02621) have been determined using Selenium-Single-wavelength Anomalous Dispersion (Se-SAD). Based on the structure, we have identified the putative function for this family of protein. CONCLUSION: Unexpectedly, we found that DUF178 Pfam is remarkably similar to Pfam family DUF191 suggesting that the sequence-based classification alone may not be sufficient to classify proteins into Pfam families.

About this Structure

2I6E is a Single protein structure of sequence from Deinococcus radiodurans. Full crystallographic information is available from OCA.

Reference

X-ray structures of two proteins belonging to Pfam DUF178 revealed unexpected structural similarity to the DUF191 Pfam family., Tyagi R, Burley SK, Swaminathan S, BMC Struct Biol. 2007 Oct 1;7:62. PMID:17908300

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