4l3t

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{{STRUCTURE_4l3t| PDB=4l3t | SCENE= }}
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==Crystal Structure of Substrate-free Human Presequence Protease==
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===Crystal Structure of Substrate-free Human Presequence Protease===
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<StructureSection load='4l3t' size='340' side='right' caption='[[4l3t]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[4l3t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L3T OCA]. <br>
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[[http://www.uniprot.org/uniprot/PREP_HUMAN PREP_HUMAN]] ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference.<ref>PMID:16849325</ref>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
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<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene>, <scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene></td></tr>
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==About this Structure==
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KIAA1104, MP1, PITRM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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[[4l3t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L3T OCA].
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l3t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l3t RCSB], [http://www.ebi.ac.uk/pdbsum/4l3t PDBsum]</span></td></tr>
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==Reference==
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<table>
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<references group="xtra"/><references/>
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== References ==
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[[Category: Homo sapiens]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Human]]
[[Category: King, J V.]]
[[Category: King, J V.]]
[[Category: Liang, W G.]]
[[Category: Liang, W G.]]

Revision as of 06:54, 14 May 2014

Crystal Structure of Substrate-free Human Presequence Protease

4l3t, resolution 2.03Å

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