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4ddk

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{{STRUCTURE_4ddk| PDB=4ddk | SCENE= }}
{{STRUCTURE_4ddk| PDB=4ddk | SCENE= }}
===Pantothenate synthetase in complex with 1,3-benzodioxole-5-carboxylic acid===
===Pantothenate synthetase in complex with 1,3-benzodioxole-5-carboxylic acid===
 +
{{ABSTRACT_PUBMED_23872845}}
==Function==
==Function==
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==Reference==
==Reference==
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<references group="xtra"/><references/>
+
<ref group="xtra">PMID:023872845</ref><references group="xtra"/><references/>
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Pantoate--beta-alanine ligase]]
[[Category: Pantoate--beta-alanine ligase]]

Revision as of 19:07, 7 August 2013

Template:STRUCTURE 4ddk

Contents

Pantothenate synthetase in complex with 1,3-benzodioxole-5-carboxylic acid

Template:ABSTRACT PUBMED 23872845

Function

[PANC_MYCTU] Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.[1]

About this Structure

4ddk is a 2 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

  • Silvestre HL, Blundell TL, Abell C, Ciulli A. Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery. Proc Natl Acad Sci U S A. 2013 Jul 19. PMID:23872845 doi:10.1073/pnas.1304045110
  1. Zheng R, Blanchard JS. Steady-state and pre-steady-state kinetic analysis of Mycobacterium tuberculosis pantothenate synthetase. Biochemistry. 2001 Oct 30;40(43):12904-12. PMID:11669627

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