4kb6

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{{STRUCTURE_4kb6| PDB=4kb6 | SCENE= }}
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==Structure of porcine cyclic GMP AMP synthase (CGAS) in complex with DNA, ATP and GTP==
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===Structure of porcine cyclic GMP AMP synthase (CGAS) in complex with DNA, ATP and GTP===
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<StructureSection load='4kb6' size='340' side='right' caption='[[4kb6]], [[Resolution|resolution]] 3.08&Aring;' scene=''>
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{{ABSTRACT_PUBMED_23722159}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4kb6]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KB6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KB6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jlx|4jlx]], [[4jlz|4jlz]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MB21D1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 Sus scrofa])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kb6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kb6 RCSB], [http://www.ebi.ac.uk/pdbsum/4kb6 PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Cytosolic DNA arising from intracellular bacterial or viral infections is a powerful pathogen-associated molecular pattern (PAMP) that leads to innate immune host defence by the production of type I interferon and inflammatory cytokines. Recognition of cytosolic DNA by the recently discovered cyclic-GMP-AMP (cGAMP) synthase (cGAS) induces the production of cGAMP to activate the stimulator of interferon genes (STING). Here we report the crystal structure of cGAS alone and in complex with DNA, ATP and GTP along with functional studies. Our results explain the broad DNA sensing specificity of cGAS, show how cGAS catalyses dinucleotide formation and indicate activation by a DNA-induced structural switch. cGAS possesses a remarkable structural similarity to the antiviral cytosolic double-stranded RNA sensor 2'-5'oligoadenylate synthase (OAS1), but contains a unique zinc thumb that recognizes B-form double-stranded DNA. Our results mechanistically unify dsRNA and dsDNA innate immune sensing by OAS1 and cGAS nucleotidyl transferases.
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==About this Structure==
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Structural mechanism of cytosolic DNA sensing by cGAS.,Civril F, Deimling T, de Oliveira Mann CC, Ablasser A, Moldt M, Witte G, Hornung V, Hopfner KP Nature. 2013 May 30. doi: 10.1038/nature12305. PMID:23722159<ref>PMID:23722159</ref>
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[[4kb6]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KB6 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:023722159</ref><references group="xtra"/><references/>
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</div>
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==See Also==
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*[[Cyclic GMP-AMP synthase|Cyclic GMP-AMP synthase]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Deimling, T.]]
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[[Category: Deimling, T]]
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[[Category: Hopfner, K P.]]
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[[Category: Hopfner, K P]]
[[Category: Cga]]
[[Category: Cga]]
[[Category: Cytosol]]
[[Category: Cytosol]]

Revision as of 14:11, 5 January 2015

Structure of porcine cyclic GMP AMP synthase (CGAS) in complex with DNA, ATP and GTP

4kb6, resolution 3.08Å

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