Transcriptional activators (TA) are proteins which bind to DNA and stimulate nearby gene transcription. TA transcription stimulation is achieved by enhancing RNA polymerase binding or by enhancing the formation of open complex which is required for initiation of transcription. TA bind to a specific DNA sequence in or near an operon via their DNA-binding domain (DBD).
3D Structures of transcriptional activator
Updated on 11-July-2013
Gcn4 TA
See Gcn4
C-Myb TA
1mse, 1msf – TA DBD + DNA - NMR
1mbe, 1mbf – mTA DBD repeat 1 + DNA – mouse - NMR
1mbg, 1mbh – mTA DBD repeat 2 + DNA - NMR
1mbj, 1mbk – mTA DBD repeat 3 + DNA - NMR
1h88 – mTA DBD + DNA + CCAAT/enhancer binding protein β
1h89 – mTA DBD + DNA + CAAT/enhancer binding protein β
1guu – mTA DBD repeat 1
1gv2 – mTA DBD repeat 2,3
1gv5 – mTA DBD repeat 2
1gvd – mTA DBD repeat 2 (mutant)
1sb0, 2agh – mTA transcription activation domain + CREB-binding protein - NMR
Psp operon TA
2bjw – EcTA AAA domain – Escherichia coli
2bjv, 2c9c – EcTA AAA domain (mutant)
2c96 – EcTA AAA domain + ATP
2c98 – EcTA AAA domain + ADP
2c99 – EcTA AAA domain + AMPPNP
2vii – EcTA AAA domain + AMP + Mg
TenA TA
1tyh, 1yaf – BsTA – Bacillus subtilis
1yak – BsTA + pyrimidine derivative
1qcx – BsTA (mutant) + pyrimidine derivative
LasR TA
2uv0 – PaTA ligand-binding domain – Pseudomonas aeruginosa
3ix3 – PaTA ligand-binding domain + oxo-dodecanoyl-homoserine lactone
3ix3, 3ix8, 3jpu – PaTA ligand-binding domain + benzoate derivative
CadC TA
3ly7, 3lya – EcTA periplasmic domain
3ly8, 3ly9 – EcTA periplasmic domain (mutant)
CynR TA
2hxr – EcTA ligand-binding domain
3hfu – EcTA ligand-binding domain + N3
Mal-Rpel TA
2v51, 2v52 – mTA residues 16-41 + actin
2yje, 2yjf – mTA Rpel domain + actin
Brg1 TA
3uvd – TA bromodomain + pyrrolidone derivative - human
VP30 TA
2i8b – TA C terminal – Zaire ebolavirus
3v7o – TA C terminal – Reston ebolavirus
