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4hsu

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{{STRUCTURE_4hsu| PDB=4hsu | SCENE= }}
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==Crystal structure of LSD2-NPAC with H3(1-26)in space group P21==
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===Crystal structure of LSD2-NPAC with H3(1-26)in space group P21===
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<StructureSection load='4hsu' size='340' side='right' caption='[[4hsu]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4hsu]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HSU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HSU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LSD2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), GLYR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hsu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hsu RCSB], [http://www.ebi.ac.uk/pdbsum/4hsu PDBsum]</span></td></tr>
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</table>
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/GLYR1_HUMAN GLYR1_HUMAN]] May have oxidoreductase activity. Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6. Recruited on chromatin, recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3).<ref>PMID:16352664</ref> <ref>PMID:20850016</ref>
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*[[Lysine-specific histone demethylase 1|Lysine-specific histone demethylase 1]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[4hsu]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HSU OCA].
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==Reference==
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<ref group="xtra">PMID:023357850</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chen, F.]]
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[[Category: Chen, F]]
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[[Category: Dong, Z.]]
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[[Category: Dong, Z]]
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[[Category: Fang, J.]]
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[[Category: Fang, J]]
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[[Category: Xu, Y.]]
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[[Category: Xu, Y]]
[[Category: Histone demethylase]]
[[Category: Histone demethylase]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]

Revision as of 12:20, 21 December 2014

Crystal structure of LSD2-NPAC with H3(1-26)in space group P21

4hsu, resolution 1.99Å

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