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2m9a

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'''Unreleased structure'''
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{{STRUCTURE_2m9a| PDB=2m9a | SCENE= }}
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===Solution NMR Structure of E3 ubiquitin-protein ligase ZFP91 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR7784A===
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The entry 2m9a is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/ZFP91_HUMAN ZFP91_HUMAN]] Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.<ref>PMID:12738986</ref> <ref>PMID:20682767</ref>
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Authors: Pederson, K., Shastry, R., Kohan, E., Janjua, H., Xiao, R., Acton, T.B., Everett, J.K., Montelione, G.T., Prestegard, J.H., Northeast Structural Genomics Consortium (NESG)
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==About this Structure==
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[[2m9a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M9A OCA].
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Description: Solution NMR Structure of E3 ubiquitin-protein ligase ZFP91 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR7784A
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Acton, T B.]]
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[[Category: Everett, J K.]]
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[[Category: Janjua, H.]]
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[[Category: Kohan, E.]]
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[[Category: Montelione, G T.]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Pederson, K.]]
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[[Category: Prestegard, J H.]]
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[[Category: Shastry, R.]]
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[[Category: Xiao, R.]]
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[[Category: C2h2]]
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[[Category: Hr7784a]]
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[[Category: Metal binding protein]]
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[[Category: Nesg]]
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[[Category: Northeast structural genomics consortium]]
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[[Category: Psi-biology]]
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[[Category: Psi:biology]]

Revision as of 13:00, 24 July 2013

Template:STRUCTURE 2m9a

Contents

Solution NMR Structure of E3 ubiquitin-protein ligase ZFP91 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR7784A

Function

[ZFP91_HUMAN] Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.[1] [2]

About this Structure

2m9a is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

  1. ↑ Unoki M, Okutsu J, Nakamura Y. Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia. Int J Oncol. 2003 Jun;22(6):1217-23. PMID:12738986
  2. ↑ Jin X, Jin HR, Jung HS, Lee SJ, Lee JH, Lee JJ. An atypical E3 ligase zinc finger protein 91 stabilizes and activates NF-kappaB-inducing kinase via Lys63-linked ubiquitination. J Biol Chem. 2010 Oct 1;285(40):30539-47. doi: 10.1074/jbc.M110.129551. Epub 2010, Aug 3. PMID:20682767 doi:10.1074/jbc.M110.129551

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