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2m9n

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'''Unreleased structure'''
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{{STRUCTURE_2m9n| PDB=2m9n | SCENE= }}
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===Solution Structure of (HhH)2 domain of human FAAP24===
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{{ABSTRACT_PUBMED_23999858}}
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The entry 2m9n is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/FAP24_HUMAN FAP24_HUMAN]] Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA.
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Authors: Wu, F., Han, X., Shi, C., Gong, W., Tian, C.
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==About this Structure==
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[[2m9n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M9N OCA].
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Description: Solution Structure of (HhH)2 domain of human FAAP24
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==Reference==
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<ref group="xtra">PMID:023999858</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Gong, W.]]
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[[Category: Han, X.]]
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[[Category: Shi, C.]]
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[[Category: Tian, C.]]
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[[Category: Wu, F.]]
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[[Category: Dna binding protein]]
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[[Category: Faap24]]
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[[Category: Fanconi anemia]]

Revision as of 04:12, 20 September 2013

Template:STRUCTURE 2m9n

Contents

Solution Structure of (HhH)2 domain of human FAAP24

Template:ABSTRACT PUBMED 23999858

Function

[FAP24_HUMAN] Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA.

About this Structure

2m9n is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

  • Wang Y, Han X, Wu F, Leung JW, Lowery MG, Do H, Chen J, Shi C, Tian C, Li L, Gong W. Structure analysis of FAAP24 reveals single-stranded DNA-binding activity and domain functions in DNA damage response. Cell Res. 2013 Sep 3. doi: 10.1038/cr.2013.124. PMID:23999858 doi:10.1038/cr.2013.124

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OCA

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