4l1o

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'''Unreleased structure'''
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{{STRUCTURE_4l1o| PDB=4l1o | SCENE= }}
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===Crystal structure of human ALDH3A1 with inhibitor 1-{[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]methyl}-1H-indole-2,3-dione===
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The entry 4l1o is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/AL3A1_HUMAN AL3A1_HUMAN]] ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes.
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Authors: Hurley, T.D., Parajuli, B.
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==About this Structure==
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[[4l1o]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L1O OCA].
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Description: Crystal structure of human ALDH3A1 with inhibitor 1-{[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]methyl}-1H-indole-2,3-dione
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[[Category: Hurley, T D.]]
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[[Category: Parajuli, B.]]
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[[Category: Catalyzes benzaldehyde]]
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[[Category: Dehydrogenase]]
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[[Category: Nadp+ binding]]
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[[Category: Oxidoreductase-inhibitor complex]]
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[[Category: Rossman fold]]

Revision as of 10:02, 16 April 2014

Template:STRUCTURE 4l1o

Crystal structure of human ALDH3A1 with inhibitor 1-{[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]methyl}-1H-indole-2,3-dione

Function

[AL3A1_HUMAN] ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes.

About this Structure

4l1o is a 2 chain structure. Full crystallographic information is available from OCA.

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OCA

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