4l9i

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'''Unreleased structure'''
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{{STRUCTURE_4l9i| PDB=4l9i | SCENE= }}
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===Bovine G Protein Coupled Receptor Kinase 1 in Complex with Paroxetine===
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{{ABSTRACT_PUBMED_24220010}}
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The entry 4l9i is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/RK_BOVIN RK_BOVIN]] Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity).
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Authors: Homan, K.T., Tesmer, J.J.G.
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==About this Structure==
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[[4l9i]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L9I OCA].
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Description: Bovine G Protein Coupled Receptor Kinase 1 in Complex with Paroxetine
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==Reference==
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<ref group="xtra">PMID:024220010</ref><references group="xtra"/><references/>
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[[Category: Rhodopsin kinase]]
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[[Category: Homan, K T.]]
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[[Category: Tesmer, J J.G.]]
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[[Category: Agc family kinase]]
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[[Category: G protein coupled receptor kinase]]
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[[Category: Gpcr]]
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[[Category: Grk]]
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[[Category: Grk1]]
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[[Category: Hydrolyase]]
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[[Category: Membrane protein-inhibitor complex]]
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[[Category: Phosphorylation]]
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[[Category: Rgs homology domain]]
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[[Category: Rhodopsin kinase]]
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[[Category: Ser/thr kinase]]
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[[Category: Ssri]]
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[[Category: Transferase]]

Revision as of 06:54, 22 January 2014

Template:STRUCTURE 4l9i

Contents

Bovine G Protein Coupled Receptor Kinase 1 in Complex with Paroxetine

Template:ABSTRACT PUBMED 24220010

Function

[RK_BOVIN] Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity).

About this Structure

4l9i is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Homan KT, Wu E, Wilson MW, Singh P, Larsen SD, Tesmer JJ. Structural and functional analysis of g protein-coupled receptor kinase inhibition by paroxetine and a rationally designed analog. Mol Pharmacol. 2014 Feb;85(2):237-48. doi: 10.1124/mol.113.089631. Epub 2013 Nov , 12. PMID:24220010 doi:http://dx.doi.org/10.1124/mol.113.089631

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OCA

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