This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4key
From Proteopedia
| Line 1: | Line 1: | ||
{{STRUCTURE_4key| PDB=4key | SCENE= }} | {{STRUCTURE_4key| PDB=4key | SCENE= }} | ||
===Structure of P450 BM3 A82F F87V in complex with omeprazole=== | ===Structure of P450 BM3 A82F F87V in complex with omeprazole=== | ||
| + | {{ABSTRACT_PUBMED_23828198}} | ||
==Function== | ==Function== | ||
| Line 7: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
[[4key]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_megaterium Bacillus megaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KEY OCA]. | [[4key]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_megaterium Bacillus megaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KEY OCA]. | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Cytochrome P450|Cytochrome P450]] | ||
| + | |||
| + | ==Reference== | ||
| + | <ref group="xtra">PMID:023828198</ref><references group="xtra"/><references/> | ||
[[Category: Bacillus megaterium]] | [[Category: Bacillus megaterium]] | ||
[[Category: Leys, D.]] | [[Category: Leys, D.]] | ||
Revision as of 06:11, 2 October 2013
Contents |
Structure of P450 BM3 A82F F87V in complex with omeprazole
Template:ABSTRACT PUBMED 23828198
Function
[CPXB_BACME] Functions as a fatty acid monooxygenase. Catalyzes hydroxylation of medium and long-chain fatty acids at omega-1, omega-2 and omega-3 positions, with optimum chain lengths of 12-16 carbons (lauric, myristic, and palmitic acids). The reductase domain is required for electron transfer from NADP to cytochrome P450.
About this Structure
4key is a 2 chain structure with sequence from Bacillus megaterium. Full crystallographic information is available from OCA.
See Also
Reference
- Butler CF, Peet C, Mason AE, Voice MW, Leys D, Munro AW. Key Mutations Alter the Cytochrome P450 BM3 Conformational Landscape and Remove Inherent Substrate Bias. J Biol Chem. 2013 Aug 30;288(35):25387-99. doi: 10.1074/jbc.M113.479717. Epub, 2013 Jul 3. PMID:23828198 doi:10.1074/jbc.M113.479717
