Dehydroquinase (DHQD) catalyzes the conversion of 3-hydroquinate to 3-hydroshikumate. DHQD is part of the shikimate pathway by which bacteria synthesize the aromatic amino acids. There are 2 types of DHQD found in different organisms. They differ in their sequence and structure. Inhibitors of DHQD are potential bacteriocides.
3D structures of dehydroquinase
Updated on 16-July-2013
DHQD-I
1qfe, 1gqn, 3l2i, 3oex, 4gfs – StDHQD – Salmonella typhi
3o1n, 4guf – StDHQD (mutant)
1sfl – SaDHQD – Staphylococcus aureus
2ocz – DHQD – Streptococcus pyrogenes
2egz, 2ysw – DHQD – Aquifex aeolicus
2yr1 – DHQD – Geobacillus kaustophilus
2ox1 – DHQD – Archaeoglobus fulgidus
3l9c – DHQD – Streptococcus mutans
DHQD-I complexes
1l9w – StDHQD + amino-dehydroxy-cyclohex-enecarboxylate
1sfj – SaDHQD + dehydroquinic acid
3js3 – CdDHQD + amino-dehydroxy-cyclohex-enecarboxylate – Clostridium difficile
3lb0 – StDHQD + citrate
3s42 – StDHQD + borate + malonate
3m7w – StDHQD + dehydroquinic acid
4gui – StDHQD + quinic acid
4iuo – StDHQD (mutant) + quinic acid
3nnt – StDHQD (mutant) + dehydroquinic acid
4gug, 4guh – StDHQD (mutant) + dehydroshikimate
4guj – StDHQD + shikimate
4h3d – CdDHQD + comenic acid
DHQD-II
1d0i, 1gu0 – ScDHQD – Streptomyces coelicolor
2dhq, 1h05 – MtDHQD – Mycobacterium tuberculosis
1gqo – DHQD – Bacillus subtilis
1uqr – DHQD – Actinobacillus pleuropneumoniae
2uyg – DHQD – Thermus thermoophilus
3lwz – DHQD – Yersinia pestis
3kip – DHQD – Candida albicans
3u80 – DHQD – Bifidobacterium longum
DHQD-II complexes
1gu1 – ScDHQD + anhydroquinic acid
1v1j – ScDHQD + anhydrofluoroquinic acid
2bt4, 2cjf – ScDHQD + inhibitor
1gtz – ScDHQD (mutant) + dehydroshikimate
1j2y – HpDHQD + dehydroquinic acid – Helicobacter pylori
1h0s – MtDHQD + hydroxyl-imino-quinic acid
1h0r – MtDHQD + anhydroquinic acid
2c4v – HpDHQD + citrate
2c4w, 2c57, 2wks, 2xb9, 2xd9, 2xda, 4b6r, 4b6s – HpDHQD + inhibitor
3n59 – MtDHQD + dehydroshikimate
3n8k – MtDHQD + citrazinic acid
2xb8, 3n76, 3n7a, 3n86, 3n87, 3n8n, 2y71, 2y76, 2y77, 4b6o, 4b6p, 4b6q – MtDHQD + inhibitor
