3utn
From Proteopedia
(Difference between revisions)
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| - | + | ==Crystal structure of Tum1 protein from Saccharomyces cerevisiae== | |
| - | === | + | <StructureSection load='3utn' size='340' side='right' caption='[[3utn]], [[Resolution|resolution]] 1.90Å' scene=''> |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3utn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UTN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UTN FirstGlance]. <br> | |
| - | ==Function== | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TUM1, YOR251C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Saccharomyces cerevisiae S288c])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiosulfate_sulfurtransferase Thiosulfate sulfurtransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.1.1 2.8.1.1] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3utn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3utn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3utn RCSB], [http://www.ebi.ac.uk/pdbsum/3utn PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
[[http://www.uniprot.org/uniprot/THTR_YEAST THTR_YEAST]] Required for formation of the 2-thio group of the 5-methoxycarbonylmethyl-2-thiouridine modified base in some tRNAs.<ref>PMID:18755837</ref> | [[http://www.uniprot.org/uniprot/THTR_YEAST THTR_YEAST]] Required for formation of the 2-thio group of the 5-methoxycarbonylmethyl-2-thiouridine modified base in some tRNAs.<ref>PMID:18755837</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Yeast tRNA-thiouridine modification protein 1 (Tum1) plays essential role in the sulfur transfer process of Urm1 system, which in turn is involved in many important cellular processes. In the rhodanese-like domain (RLD), conserved cysteine residue is proved to be the centre of active site of sulfurtransferases and crucial for the substrate recognition. In this report, we describe the crystal structure of Tum1 protein at 1.90 A resolution which, despite consisting of two RLDs, has only one conserved cysteine residue in the C-terminal RLD. An unaccounted electron density is found near the active site, which might point to the new cofactor in the sulfur transfer mechanism. | ||
| + | |||
| + | Crystal structure of the Tum1 protein from the yeast Saccharomyces cerevisiae.,Qiu R, Wang F, Liu M, Lou T, Ji C Protein Pept Lett. 2012 May 8. PMID:22587783<ref>PMID:22587783</ref> | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | == | + | ==See Also== |
| - | + | *[[Sulfurtransferase|Sulfurtransferase]] | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Saccharomyces cerevisiae s288c]] | [[Category: Saccharomyces cerevisiae s288c]] | ||
[[Category: Thiosulfate sulfurtransferase]] | [[Category: Thiosulfate sulfurtransferase]] | ||
| - | [[Category: Gong, W | + | [[Category: Gong, W]] |
| - | [[Category: Ji, C | + | [[Category: Ji, C]] |
| - | [[Category: Liu, M | + | [[Category: Liu, M]] |
| - | [[Category: Qiu, R | + | [[Category: Qiu, R]] |
| - | [[Category: Wang, F | + | [[Category: Wang, F]] |
[[Category: Rhodanese-like domain]] | [[Category: Rhodanese-like domain]] | ||
[[Category: Sulfurtransferase]] | [[Category: Sulfurtransferase]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 14:10, 25 December 2014
Crystal structure of Tum1 protein from Saccharomyces cerevisiae
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