4f4b
From Proteopedia
(Difference between revisions)
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| - | + | ==Structure of OSH4 with a cholesterol analog== | |
| - | === | + | <StructureSection load='4f4b' size='340' side='right' caption='[[4f4b]], [[Resolution|resolution]] 1.87Å' scene=''> |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4f4b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F4B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F4B FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=L39:(3BETA,9BETA,25R)-3-HYDROXY-26-IODOCHOLEST-5-ENE-16,22-DIONE'>L39</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zhy|1zhy]], [[1zhx|1zhx]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KES1, OSH4, YPL145C, LPI3C, P2614 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Saccharomyces cerevisiae S288c])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f4b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f4b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4f4b RCSB], [http://www.ebi.ac.uk/pdbsum/4f4b PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | We have synthesized 16,22-diketocholesterol, a novel ligand for oxysterol-binding protein Osh4, and determined X-ray structure of the diketocholesterol in complex with Osh4. The X-ray structure shows that alpha7 helix of Osh4 assumes open conformation while the rest of Osh4, closed conformation, implying this diketocholesterol-bound Osh4 structure may represent a structural intermediate between the two conformations. | ||
| - | + | Synthesis and structure of 16,22-diketocholesterol bound to oxysterol-binding protein Osh4.,Koag MC, Cheun Y, Kou Y, Ouzon-Shubeita H, Min K, Monzingo AF, Lee S Steroids. 2013 Jun 10;78(9):938-944. doi: 10.1016/j.steroids.2013.05.016. PMID:23756172<ref>PMID:23756172</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Saccharomyces cerevisiae s288c]] | [[Category: Saccharomyces cerevisiae s288c]] | ||
| - | [[Category: Cheun, Y | + | [[Category: Cheun, Y]] |
| - | [[Category: Koag, M C | + | [[Category: Koag, M C]] |
| - | [[Category: Lee, S | + | [[Category: Lee, S]] |
| - | [[Category: Monzingo, A F | + | [[Category: Monzingo, A F]] |
[[Category: Lipid binding protein]] | [[Category: Lipid binding protein]] | ||
[[Category: Oxysterol]] | [[Category: Oxysterol]] | ||
[[Category: Sterol binding protein]] | [[Category: Sterol binding protein]] | ||
Revision as of 14:19, 4 January 2015
Structure of OSH4 with a cholesterol analog
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