4f0b
From Proteopedia
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| - | + | ==Crystal structure of the glutathione transferase URE2P1 from Phanerochaete chrysosporium.== | |
| - | + | <StructureSection load='4f0b' size='340' side='right' caption='[[4f0b]], [[Resolution|resolution]] 1.45Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4f0b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Phanerochaete_chrysosporium Phanerochaete chrysosporium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F0B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F0B FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDS:OXIDIZED+GLUTATHIONE+DISULFIDE'>GDS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4f0c|4f0c]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f0b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4f0b RCSB], [http://www.ebi.ac.uk/pdbsum/4f0b PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Glutathione transferases (GSTs) are known to transfer glutathione onto small hydrophobic molecules in detoxification reactions. The GST Ure2pB1 from Phanerochaete chrysosporium exhibits atypical features, i.e. the presence of two glutathione binding sites and a high affinity towards oxidized glutathione. Moreover, PcUre2pB1 is able to efficiently deglutathionylate GS-phenacylacetophenone. Catalysis is not mediated by the cysteines of the protein but rather by the one of glutathione and an asparagine residue plays a key role in glutathione stabilization. Interestingly PcUre2pB1 interacts in vitro with a GST of the omega class. These properties are discussed in the physiological context of wood degrading fungi. | ||
| - | + | Atypical features of a Ure2p glutathione transferase from Phanerochaete chrysosporium.,Thuillier A, Roret T, Favier F, Gelhaye E, Jacquot JP, Didierjean C, Morel-Rouhier M FEBS Lett. 2013 Jul 11;587(14):2125-30. doi: 10.1016/j.febslet.2013.05.031. Epub , 2013 May 24. PMID:23711374<ref>PMID:23711374</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Phanerochaete chrysosporium]] | [[Category: Phanerochaete chrysosporium]] | ||
| - | [[Category: Didierjean, C | + | [[Category: Didierjean, C]] |
| - | [[Category: Favier, F | + | [[Category: Favier, F]] |
| - | [[Category: Roret, T | + | [[Category: Roret, T]] |
[[Category: Gst fold]] | [[Category: Gst fold]] | ||
[[Category: Oxydized glutathione]] | [[Category: Oxydized glutathione]] | ||
[[Category: Thiol transferase]] | [[Category: Thiol transferase]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 10:59, 21 December 2014
Crystal structure of the glutathione transferase URE2P1 from Phanerochaete chrysosporium.
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