4lg2
From Proteopedia
| Line 7: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | [[4lg2]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[4lg2]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Eborr Eborr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LG2 OCA]. |
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:023824825</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:023824825</ref><references group="xtra"/><references/> | ||
| + | [[Category: Eborr]] | ||
[[Category: Bale, S.]] | [[Category: Bale, S.]] | ||
[[Category: Bornholdt, Z A.]] | [[Category: Bornholdt, Z A.]] | ||
Revision as of 08:51, 27 November 2013
Contents |
Crystal structure of Reston Ebola virus VP35 RNA binding domain bound to 12-bp dsRNA
Template:ABSTRACT PUBMED 23824825
Function
[VP35_EBORR] Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (By similarity).
About this Structure
4lg2 is a 8 chain structure with sequence from Eborr. Full crystallographic information is available from OCA.
Reference
- Bale S, Julien JP, Bornholdt ZA, Krois AS, Wilson IA, Saphire EO. Ebolavirus VP35 also coats the backbone of dsRNA for interferon antagonism. J Virol. 2013 Jul 3. PMID:23824825 doi:10.1128/JVI.01452-13
