4jkt
From Proteopedia
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| - | + | {{STRUCTURE_4jkt| PDB=4jkt | SCENE= }} | |
| + | ===Crystal structure of mouse Glutaminase C, BPTES-bound form=== | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/GLSK_MOUSE GLSK_MOUSE]] Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain.<ref>PMID:16641247</ref> <ref>PMID:22373647</ref> <ref>PMID:22228304</ref> | ||
| - | + | ==About this Structure== | |
| + | [[4jkt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JKT OCA]. | ||
| - | + | ==Reference== | |
| + | <references group="xtra"/><references/> | ||
| + | [[Category: Glutaminase]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Ambrosio, A L.B.]] | ||
| + | [[Category: Dias, S M.G.]] | ||
| + | [[Category: Ferreira, A P.S.]] | ||
| + | [[Category: Fornezari, C.]] | ||
| + | [[Category: Glutaminase]] | ||
| + | [[Category: Hydrolase]] | ||
Revision as of 08:00, 14 August 2013
Contents |
Crystal structure of mouse Glutaminase C, BPTES-bound form
Function
[GLSK_MOUSE] Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain.[1] [2] [3]
About this Structure
4jkt is a 4 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
- ↑ Masson J, Darmon M, Conjard A, Chuhma N, Ropert N, Thoby-Brisson M, Foutz AS, Parrot S, Miller GM, Jorisch R, Polan J, Hamon M, Hen R, Rayport S. Mice lacking brain/kidney phosphate-activated glutaminase have impaired glutamatergic synaptic transmission, altered breathing, disorganized goal-directed behavior and die shortly after birth. J Neurosci. 2006 Apr 26;26(17):4660-71. PMID:16641247 doi:10.1523/JNEUROSCI.4241-05.2006
- ↑ El Hage M, Masson J, Conjard-Duplany A, Ferrier B, Baverel G, Martin G. Brain slices from glutaminase-deficient mice metabolize less glutamine: a cellular metabolomic study with carbon 13 NMR. J Cereb Blood Flow Metab. 2012 May;32(5):816-24. doi: 10.1038/jcbfm.2012.22. Epub, 2012 Feb 29. PMID:22373647 doi:10.1038/jcbfm.2012.22
- ↑ Cassago A, Ferreira AP, Ferreira IM, Fornezari C, Gomes ER, Greene KS, Pereira HM, Garratt RC, Dias SM, Ambrosio AL. Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism. Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1092-7. Epub 2012 Jan 6. PMID:22228304 doi:10.1073/pnas.1112495109
