This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4jkt

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4jkt| PDB=4jkt | SCENE= }}
 +
===Crystal structure of mouse Glutaminase C, BPTES-bound form===
-
The entry 4jkt is ON HOLD
+
==Function==
 +
[[http://www.uniprot.org/uniprot/GLSK_MOUSE GLSK_MOUSE]] Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain.<ref>PMID:16641247</ref> <ref>PMID:22373647</ref> <ref>PMID:22228304</ref>
-
Authors: Fornezari, C., Ferreira, A.P.S., Dias, S.M.G., Ambrosio, A.L.B.
+
==About this Structure==
 +
[[4jkt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JKT OCA].
-
Description: Crystal structure of mouse Glutaminase C, BPTES-bound form
+
==Reference==
 +
<references group="xtra"/><references/>
 +
[[Category: Glutaminase]]
 +
[[Category: Mus musculus]]
 +
[[Category: Ambrosio, A L.B.]]
 +
[[Category: Dias, S M.G.]]
 +
[[Category: Ferreira, A P.S.]]
 +
[[Category: Fornezari, C.]]
 +
[[Category: Glutaminase]]
 +
[[Category: Hydrolase]]

Revision as of 08:00, 14 August 2013

Template:STRUCTURE 4jkt

Contents

Crystal structure of mouse Glutaminase C, BPTES-bound form

Function

[GLSK_MOUSE] Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain.[1] [2] [3]

About this Structure

4jkt is a 4 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  1. ↑ Masson J, Darmon M, Conjard A, Chuhma N, Ropert N, Thoby-Brisson M, Foutz AS, Parrot S, Miller GM, Jorisch R, Polan J, Hamon M, Hen R, Rayport S. Mice lacking brain/kidney phosphate-activated glutaminase have impaired glutamatergic synaptic transmission, altered breathing, disorganized goal-directed behavior and die shortly after birth. J Neurosci. 2006 Apr 26;26(17):4660-71. PMID:16641247 doi:10.1523/JNEUROSCI.4241-05.2006
  2. ↑ El Hage M, Masson J, Conjard-Duplany A, Ferrier B, Baverel G, Martin G. Brain slices from glutaminase-deficient mice metabolize less glutamine: a cellular metabolomic study with carbon 13 NMR. J Cereb Blood Flow Metab. 2012 May;32(5):816-24. doi: 10.1038/jcbfm.2012.22. Epub, 2012 Feb 29. PMID:22373647 doi:10.1038/jcbfm.2012.22
  3. ↑ Cassago A, Ferreira AP, Ferreira IM, Fornezari C, Gomes ER, Greene KS, Pereira HM, Garratt RC, Dias SM, Ambrosio AL. Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism. Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1092-7. Epub 2012 Jan 6. PMID:22228304 doi:10.1073/pnas.1112495109

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4jkt"
Personal tools