4lmf

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m (Protected "4lmf" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4lmf| PDB=4lmf | SCENE= }}
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===C1s CUB1-EGF-CUB2===
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The entry 4lmf is ON HOLD
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==Disease==
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[[http://www.uniprot.org/uniprot/C1S_HUMAN C1S_HUMAN]] Defects in C1S are the cause of complement component C1s deficiency (C1SD) [MIM:[http://omim.org/entry/613783 613783]]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.
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Authors: Wallis, R., Venkatraman Girija, U., Moody, P.C.E, Marshall, J.E
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==Function==
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[[http://www.uniprot.org/uniprot/C1S_HUMAN C1S_HUMAN]] C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.
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Description: C1s CUB1-EGF-CUB2
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==About this Structure==
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[[4lmf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LMF OCA].
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[[Category: Complement subcomponent C1s]]
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[[Category: Homo sapiens]]
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[[Category: Girija, U Venkatraman.]]
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[[Category: Marshall, J E]]
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[[Category: Moody, P C.E]]
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[[Category: Wallis, R.]]
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[[Category: Complement c1]]
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[[Category: Cub domain]]
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[[Category: Egf-like domain]]
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[[Category: Hydrolase]]

Revision as of 21:04, 7 August 2013

Template:STRUCTURE 4lmf

Contents

C1s CUB1-EGF-CUB2

Disease

[C1S_HUMAN] Defects in C1S are the cause of complement component C1s deficiency (C1SD) [MIM:613783]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.

Function

[C1S_HUMAN] C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.

About this Structure

4lmf is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

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OCA

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