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2ipy
From Proteopedia
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| - | [[Image:2ipy.gif|left|200px]] | + | [[Image:2ipy.gif|left|200px]] |
| - | + | ||
| - | '''crystal structure of iron regulatory protein 1 in complex with ferritin H IRE-RNA''' | + | {{Structure |
| + | |PDB= 2ipy |SIZE=350|CAPTION= <scene name='initialview01'>2ipy</scene>, resolution 2.80Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Aconitate_hydratase Aconitate hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.3 4.2.1.3] | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''crystal structure of iron regulatory protein 1 in complex with ferritin H IRE-RNA''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2IPY is a [ | + | 2IPY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. The following page contains interesting information on the relation of 2IPY with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb89_1.html Aconitase and Iron Regulatory Protein 1]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IPY OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of dual function iron regulatory protein 1 complexed with ferritin IRE-RNA., Walden WE, Selezneva AI, Dupuy J, Volbeda A, Fontecilla-Camps JC, Theil EC, Volz K, Science. 2006 Dec 22;314(5807):1903-8. PMID:[http:// | + | Structure of dual function iron regulatory protein 1 complexed with ferritin IRE-RNA., Walden WE, Selezneva AI, Dupuy J, Volbeda A, Fontecilla-Camps JC, Theil EC, Volz K, Science. 2006 Dec 22;314(5807):1903-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17185597 17185597] |
[[Category: Aconitase and Iron Regulatory Protein 1]] | [[Category: Aconitase and Iron Regulatory Protein 1]] | ||
[[Category: Aconitate hydratase]] | [[Category: Aconitate hydratase]] | ||
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[[Category: protein-rna complex]] | [[Category: protein-rna complex]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:32:13 2008'' |
Revision as of 15:32, 20 March 2008
| |||||||
| , resolution 2.80Å | |||||||
|---|---|---|---|---|---|---|---|
| Activity: | Aconitate hydratase, with EC number 4.2.1.3 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
crystal structure of iron regulatory protein 1 in complex with ferritin H IRE-RNA
Overview
Iron regulatory protein 1 (IRP1) binds iron-responsive elements (IREs) in messenger RNAs (mRNAs), to repress translation or degradation, or binds an iron-sulfur cluster, to become a cytosolic aconitase enzyme. The 2.8 angstrom resolution crystal structure of the IRP1:ferritin H IRE complex shows an open protein conformation compared with that of cytosolic aconitase. The extended, L-shaped IRP1 molecule embraces the IRE stem-loop through interactions at two sites separated by approximately 30 angstroms, each involving about a dozen protein:RNA bonds. Extensive conformational changes related to binding the IRE or an iron-sulfur cluster explain the alternate functions of IRP1 as an mRNA regulator or enzyme.
About this Structure
2IPY is a Single protein structure of sequence from Oryctolagus cuniculus. The following page contains interesting information on the relation of 2IPY with [Aconitase and Iron Regulatory Protein 1]. Full crystallographic information is available from OCA.
Reference
Structure of dual function iron regulatory protein 1 complexed with ferritin IRE-RNA., Walden WE, Selezneva AI, Dupuy J, Volbeda A, Fontecilla-Camps JC, Theil EC, Volz K, Science. 2006 Dec 22;314(5807):1903-8. PMID:17185597
Page seeded by OCA on Thu Mar 20 17:32:13 2008
