4k5y

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{{STRUCTURE_4k5y| PDB=4k5y | SCENE= }}
{{STRUCTURE_4k5y| PDB=4k5y | SCENE= }}
===Crystal structure of human corticotropin-releasing factor receptor 1 (CRF1R) in complex with the antagonist CP-376395===
===Crystal structure of human corticotropin-releasing factor receptor 1 (CRF1R) in complex with the antagonist CP-376395===
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{{ABSTRACT_PUBMED_23863939}}
==Function==
==Function==
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==Reference==
==Reference==
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<references group="xtra"/><references/>
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<ref group="xtra">PMID:023863939</ref><references group="xtra"/><references/>
[[Category: Bortolato, A.]]
[[Category: Bortolato, A.]]
[[Category: Cheng, R K.Y.]]
[[Category: Cheng, R K.Y.]]

Revision as of 05:14, 23 October 2013

Template:STRUCTURE 4k5y

Contents

Crystal structure of human corticotropin-releasing factor receptor 1 (CRF1R) in complex with the antagonist CP-376395

Template:ABSTRACT PUBMED 23863939

Function

[CRFR1_HUMAN] Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.[1]

About this Structure

4k5y is a 3 chain structure. Full crystallographic information is available from OCA.

Reference

  • Hollenstein K, Kean J, Bortolato A, Cheng RK, Dore AS, Jazayeri A, Cooke RM, Weir M, Marshall FH. Structure of class B GPCR corticotropin-releasing factor receptor 1. Nature. 2013 Jul 25;499(7459):438-43. doi: 10.1038/nature12357. Epub 2013 Jul 17. PMID:23863939 doi:http://dx.doi.org/10.1038/nature12357
  1. ↑ Pioszak AA, Parker NR, Suino-Powell K, Xu HE. Molecular recognition of corticotropin-releasing factor by its G-protein-coupled receptor CRFR1. J Biol Chem. 2008 Nov 21;283(47):32900-12. Epub 2008 Sep 17. PMID:18801728 doi:10.1074/jbc.M805749200

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OCA

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