This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4k6l
From Proteopedia
| Line 1: | Line 1: | ||
{{STRUCTURE_4k6l| PDB=4k6l | SCENE= }} | {{STRUCTURE_4k6l| PDB=4k6l | SCENE= }} | ||
===Structure of Typhoid Toxin=== | ===Structure of Typhoid Toxin=== | ||
| + | {{ABSTRACT_PUBMED_23842500}} | ||
==Function== | ==Function== | ||
| Line 7: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
[[4k6l]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhi Salmonella enterica subsp. enterica serovar typhi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K6L OCA]. | [[4k6l]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhi Salmonella enterica subsp. enterica serovar typhi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K6L OCA]. | ||
| + | |||
| + | ==Reference== | ||
| + | <ref group="xtra">PMID:023842500</ref><references group="xtra"/><references/> | ||
[[Category: Salmonella enterica subsp. enterica serovar typhi]] | [[Category: Salmonella enterica subsp. enterica serovar typhi]] | ||
[[Category: Galan,J.]] | [[Category: Galan,J.]] | ||
Revision as of 11:37, 24 July 2013
Contents |
Structure of Typhoid Toxin
Template:ABSTRACT PUBMED 23842500
Function
[CDTB_SALTI] Produces a CDT (cytolethal distending toxin) activity, which causes DNA damage in intoxicated cells. This damage induces G2/M cell cycle arrest, chromatin fragmentation, cell distention and nucleus enlargement.
About this Structure
4k6l is a 7 chain structure with sequence from Salmonella enterica subsp. enterica serovar typhi. Full crystallographic information is available from OCA.
Reference
- Song J, Gao X, Galan JE. Structure and function of the Salmonella Typhi chimaeric A(2)B(5) typhoid toxin. Nature. 2013 Jul 18;499(7458):350-4. doi: 10.1038/nature12377. Epub 2013 Jul 10. PMID:23842500 doi:10.1038/nature12377
