We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.
4keo
From Proteopedia
(Difference between revisions)
proteopedia linkproteopedia link
|
|
| Line 1: |
Line 1: |
| - | {{STRUCTURE_4keo| PDB=4keo | SCENE= }}
| + | #REDIRECT [[4lrh]] This PDB entry is obsolete and replaced by 4lrh |
| - | ===Structure of human folate receptor alpha in complex with folic acid===
| + | |
| - | | + | |
| - | ==Disease==
| + | |
| - | [[http://www.uniprot.org/uniprot/FOLR1_HUMAN FOLR1_HUMAN]] Neurodegenerative syndrome due to cerebral folate transport deficiency. Neurodegeneration due to cerebral folate transport deficiency (NCFTD) [MIM:[http://omim.org/entry/613068 613068]]: A neurodegenerative disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy and leukodystrophy. Note=The disease is caused by mutations affecting the gene represented in this entry. | + | |
| - | | + | |
| - | ==Function==
| + | |
| - | [[http://www.uniprot.org/uniprot/FOLR1_HUMAN FOLR1_HUMAN]] Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.
| + | |
| - | | + | |
| - | ==About this Structure==
| + | |
| - | [[4keo]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KEO OCA].
| + | |
| - | [[Category: Homo sapiens]]
| + | |
| - | [[Category: Brunzelle, J S.]]
| + | |
| - | [[Category: Chen, C.]]
| + | |
| - | [[Category: Ke, J.]]
| + | |
| - | [[Category: Li, J.]]
| + | |
| - | [[Category: Melcher, K.]]
| + | |
| - | [[Category: Xu, H E.]]
| + | |
| - | [[Category: Yi, W.]]
| + | |
| - | [[Category: Young, E L.]]
| + | |
| - | [[Category: Zhou, X E.]]
| + | |
| - | [[Category: Cysteine-rich glycoprotein]]
| + | |
| - | [[Category: Folate binding protein]]
| + | |
| - | [[Category: Folate receptor]]
| + | |
| - | [[Category: Folic acid binding]]
| + | |
| - | [[Category: Frizzled-like fold]]
| + | |
| - | [[Category: Frizzled-like structure]]
| + | |
| - | [[Category: Membrane]]
| + | |
| - | [[Category: Receptor-ligand complex]]
| + | |
Current revision
- REDIRECT 4lrh This PDB entry is obsolete and replaced by 4lrh
