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4keo

From Proteopedia

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Current revision (04:56, 1 August 2013) (edit) (undo)
(Redirecting to 4lrh)
 
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{{STRUCTURE_4keo| PDB=4keo | SCENE= }}
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#REDIRECT [[4lrh]] This PDB entry is obsolete and replaced by 4lrh
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===Structure of human folate receptor alpha in complex with folic acid===
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==Disease==
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[[http://www.uniprot.org/uniprot/FOLR1_HUMAN FOLR1_HUMAN]] Neurodegenerative syndrome due to cerebral folate transport deficiency. Neurodegeneration due to cerebral folate transport deficiency (NCFTD) [MIM:[http://omim.org/entry/613068 613068]]: A neurodegenerative disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy and leukodystrophy. Note=The disease is caused by mutations affecting the gene represented in this entry.
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==Function==
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[[http://www.uniprot.org/uniprot/FOLR1_HUMAN FOLR1_HUMAN]] Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.
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==About this Structure==
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[[4keo]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KEO OCA].
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[[Category: Homo sapiens]]
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[[Category: Brunzelle, J S.]]
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[[Category: Chen, C.]]
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[[Category: Ke, J.]]
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[[Category: Li, J.]]
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[[Category: Melcher, K.]]
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[[Category: Xu, H E.]]
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[[Category: Yi, W.]]
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[[Category: Young, E L.]]
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[[Category: Zhou, X E.]]
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[[Category: Cysteine-rich glycoprotein]]
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[[Category: Folate binding protein]]
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[[Category: Folate receptor]]
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[[Category: Folic acid binding]]
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[[Category: Frizzled-like fold]]
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[[Category: Frizzled-like structure]]
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[[Category: Membrane]]
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[[Category: Receptor-ligand complex]]
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Current revision

  1. REDIRECT 4lrh This PDB entry is obsolete and replaced by 4lrh

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