Lysine-specific histone demethylase
From Proteopedia
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[[2com]], [[2l3d]] - hLSD1 SWIRM domain – human – NMR<br /> | [[2com]], [[2l3d]] - hLSD1 SWIRM domain – human – NMR<br /> | ||
| - | [[2h94]], [[2dw4]], [[2z3y]], [[2z5u]] – hLSD1<br /> | + | [[2h94]], [[2dw4]], [[2z3y]], [[2z5u]], [[4fwe]], [[4fwj]], [[4gu1]] – hLSD1<br /> |
[[2hko]] – hLSD1 (mutant)<br /> | [[2hko]] – hLSD1 (mutant)<br /> | ||
| - | [[2ejr]], [[3abt]], [[3abu]] – hLSD1 + tranylcypromine derivative | + | [[2ejr]], [[3abt]], [[3abu]] – hLSD1 + tranylcypromine derivative<br /> |
| + | [[4fwf]] – hLSD1 + histone 3.1 peptide<br /> | ||
| + | [[4gu0]] – hLSD1 + histone 3.3 peptide<br /> | ||
| + | [[4gur]], [[4gus]], [[4hsu]] – hLSD1 + histone 3.3 peptide + oxidoreductase<br /> | ||
| + | [[4gut]], [[4guu]] – hLSD1 + oxidoreductase<br /> | ||
'''LSD1 complex with CoREST''' | '''LSD1 complex with CoREST''' | ||
Revision as of 09:24, 23 March 2014
Lysine-specific histone demethylase 1 (LSD1) is a flavin-dependent oxidase that catalyzes the removal of methyl groups from mono- and dimethylated lysine 4 of histone H3. LSD1 is a nuclear homolog of amine oxidase. It functions as histone demethylase and transcriptional corepressor. LSD1 demethylation occurs via a reaction which produces formaldehyde. LSD1 is a component of transcriptional corepressor complex which also contains CoREST (corepressor of element-1-silencing transcription factor).
3D structures of lysine-specific histone demethylase 1
Updated on 23-March-2014
2com, 2l3d - hLSD1 SWIRM domain – human – NMR
2h94, 2dw4, 2z3y, 2z5u, 4fwe, 4fwj, 4gu1 – hLSD1
2hko – hLSD1 (mutant)
2ejr, 3abt, 3abu – hLSD1 + tranylcypromine derivative
4fwf – hLSD1 + histone 3.1 peptide
4gu0 – hLSD1 + histone 3.3 peptide
4gur, 4gus, 4hsu – hLSD1 + histone 3.3 peptide + oxidoreductase
4gut, 4guu – hLSD1 + oxidoreductase
LSD1 complex with CoREST
2iw5, 2uxn, 2uxx - hLSD1 SWIRM + amine oxidase domains + CoREST SANT1 and SANT2 domains
2v1d - hLSD1 residues 123-852 + CoREST SANT1 and SANT2 domains + histone H3 residues 2-22 (mutant)
2x0l - hLSD1 residues 123-852 + CoREST SANT1 and SANT2 domains + histone H3 residues 1-16
2xaf, 2xag, 2xah, 2xaj, 2xaq, 2xas - hLSD1 residues 123-852 + CoREST SANT1 and SANT2 domains + tranylcypromine derivative
2y48 - hLSD1 residues 123-852 + CoREST SANT1 and SANT2 domains + zinc finger protein SNAIL N terminal
3zms, 3zmt, 3zmu, 3zmv, 3zmz, 3zn0, 3zn1 - hLSD1 residues 123-852 + CoREST SANT1 and SANT2 domains + zinc finger protein IA-1 peptide
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
