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4kty

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4kty| PDB=4kty | SCENE= }}
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===Fibrin-stabilizing factor with a bound ligand===
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{{ABSTRACT_PUBMED_24115223}}
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The entry 4kty is ON HOLD until Paper Publication
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==Disease==
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[[http://www.uniprot.org/uniprot/F13A_HUMAN F13A_HUMAN]] Defects in F13A1 are the cause of factor XIII subunit A deficiency (FA13AD) [MIM:[http://omim.org/entry/613225 613225]]. FA13AD is an autosomal recessive disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women.<ref>PMID:1353995</ref>
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Authors: Stieler, M., Heine, A., Klebe, G.
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==Function==
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[[http://www.uniprot.org/uniprot/F13A_HUMAN F13A_HUMAN]] Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
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Description: Fibrin-stabilizing factor with a bound ligand
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==About this Structure==
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[[4kty]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KTY OCA].
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==Reference==
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<ref group="xtra">PMID:024115223</ref><references group="xtra"/><references/>
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[[Category: Protein-glutamine gamma-glutamyltransferase]]
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[[Category: Heine, A.]]
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[[Category: Klebe, G.]]
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[[Category: Stieler, M.]]
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[[Category: Acyltransferase]]
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[[Category: Calcium ion]]
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[[Category: Coagulation]]
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[[Category: Ligand]]
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[[Category: Transferase]]
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[[Category: Transferase-transferase inhibitor complex]]
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[[Category: Transglutaminase]]

Revision as of 07:17, 4 December 2013

Template:STRUCTURE 4kty

Contents

Fibrin-stabilizing factor with a bound ligand

Template:ABSTRACT PUBMED 24115223

Disease

[F13A_HUMAN] Defects in F13A1 are the cause of factor XIII subunit A deficiency (FA13AD) [MIM:613225]. FA13AD is an autosomal recessive disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women.[1]

Function

[F13A_HUMAN] Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.

About this Structure

4kty is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  • Stieler M, Weber J, Hils M, Kolb P, Heine A, Buchold C, Pasternack R, Klebe G. Structure of Active Coagulation Factor XIII Triggered by Calcium Binding: Basis for the Design of Next-Generation Anticoagulants. Angew Chem Int Ed Engl. 2013 Sep 20. doi: 10.1002/anie.201305133. PMID:24115223 doi:http://dx.doi.org/10.1002/anie.201305133
  1. ↑ Board P, Coggan M, Miloszewski K. Identification of a point mutation in factor XIII A subunit deficiency. Blood. 1992 Aug 15;80(4):937-41. PMID:1353995

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