4kxt

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'''Unreleased structure'''
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{{STRUCTURE_4kxt| PDB=4kxt | SCENE= }}
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===Structure of human ARGONAUTE1 in complex with guide RNA===
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{{ABSTRACT_PUBMED_23809764}}
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The entry 4kxt is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/AGO1_HUMAN AGO1_HUMAN]] Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs).<ref>PMID:16289642</ref> <ref>PMID:16936728</ref> <ref>PMID:18771919</ref>
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Authors: Nakanishi, K., Patel, D.J.
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==About this Structure==
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[[4kxt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Spodoptera_frugiperda Spodoptera frugiperda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KXT OCA].
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Description: Structure of human ARGONAUTE1 in complex with guide RNA
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==Reference==
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<ref group="xtra">PMID:023809764</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Spodoptera frugiperda]]
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[[Category: Nakanishi, K.]]
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[[Category: Patel, D J.]]
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[[Category: Hydrolase-rna complex]]
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[[Category: Nuclease]]
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[[Category: Rna]]
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[[Category: Rnase h fold]]

Revision as of 05:24, 1 August 2013

Template:STRUCTURE 4kxt

Contents

Structure of human ARGONAUTE1 in complex with guide RNA

Template:ABSTRACT PUBMED 23809764

Function

[AGO1_HUMAN] Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs).[1] [2] [3]

About this Structure

4kxt is a 2 chain structure with sequence from Homo sapiens and Spodoptera frugiperda. Full crystallographic information is available from OCA.

Reference

  • Nakanishi K, Ascano M, Gogakos T, Ishibe-Murakami S, Serganov AA, Briskin D, Morozov P, Tuschl T, Patel DJ. Eukaryote-Specific Insertion Elements Control Human ARGONAUTE Slicer Activity. Cell Rep. 2013 Jun 27;3(6):1893-900. doi: 10.1016/j.celrep.2013.06.010. PMID:23809764 doi:10.1016/j.celrep.2013.06.010
  1. ↑ Meister G, Landthaler M, Peters L, Chen PY, Urlaub H, Luhrmann R, Tuschl T. Identification of novel argonaute-associated proteins. Curr Biol. 2005 Dec 6;15(23):2149-55. Epub 2005 Nov 10. PMID:16289642 doi:10.1016/j.cub.2005.10.048
  2. ↑ Janowski BA, Huffman KE, Schwartz JC, Ram R, Nordsell R, Shames DS, Minna JD, Corey DR. Involvement of AGO1 and AGO2 in mammalian transcriptional silencing. Nat Struct Mol Biol. 2006 Sep;13(9):787-92. Epub 2006 Aug 27. PMID:16936728 doi:nsmb1140
  3. ↑ Wu L, Fan J, Belasco JG. Importance of translation and nonnucleolytic ago proteins for on-target RNA interference. Curr Biol. 2008 Sep 9;18(17):1327-32. doi: 10.1016/j.cub.2008.07.072. PMID:18771919 doi:10.1016/j.cub.2008.07.072

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