2ix7

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[[Image:2ix7.gif|left|200px]]<br /><applet load="2ix7" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2ix7.gif|left|200px]]
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caption="2ix7, resolution 2.50&Aring;" />
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'''STRUCTURE OF APO-CALMODULIN BOUND TO UNCONVENTIONAL MYOSIN V'''<br />
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{{Structure
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|PDB= 2ix7 |SIZE=350|CAPTION= <scene name='initialview01'>2ix7</scene>, resolution 2.50&Aring;
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|SITE= <scene name='pdbsite=AC1:CYS+Binding+Site+For+Chain+C'>AC1</scene>
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=CYS:CYSTEINE'>CYS</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''STRUCTURE OF APO-CALMODULIN BOUND TO UNCONVENTIONAL MYOSIN V'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2IX7 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=CYS:'>CYS</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:CYS+Binding+Site+For+Chain+C'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IX7 OCA].
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2IX7 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IX7 OCA].
==Reference==
==Reference==
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Crystal structure of apo-calmodulin bound to the first two IQ motifs of myosin V reveals essential recognition features., Houdusse A, Gaucher JF, Krementsova E, Mui S, Trybus KM, Cohen C, Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19326-31. Epub 2006 Dec 6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17151196 17151196]
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Crystal structure of apo-calmodulin bound to the first two IQ motifs of myosin V reveals essential recognition features., Houdusse A, Gaucher JF, Krementsova E, Mui S, Trybus KM, Cohen C, Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19326-31. Epub 2006 Dec 6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17151196 17151196]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: ubl conjugation]]
[[Category: ubl conjugation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:56:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:34:34 2008''

Revision as of 15:34, 20 March 2008

Image:2ix7.gif


PDB ID 2ix7

Drag the structure with the mouse to rotate
, resolution 2.50Å
Sites:
Ligands: and
Coordinates: save as pdb, mmCIF, xml



STRUCTURE OF APO-CALMODULIN BOUND TO UNCONVENTIONAL MYOSIN V


Overview

A 2.5-A resolution structure of calcium-free calmodulin (CaM) bound to the first two IQ motifs of the murine myosin V heavy chain reveals an unusual CaM conformation. The C-terminal lobe of each CaM adopts a semi-open conformation that grips the first part of the IQ motif (IQxxxR), whereas the N-terminal lobe adopts a closed conformation that interacts more weakly with the second part of the motif (GxxxR). Variable residues in the IQ motif play a critical role in determining the precise structure of the bound CaM, such that even the consensus residues of different motifs show unique interactions with CaM. This complex serves as a model for the lever arm region of many classes of unconventional myosins, as well as other IQ motif-containing proteins such as neuromodulin and IQGAPs.

About this Structure

2IX7 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of apo-calmodulin bound to the first two IQ motifs of myosin V reveals essential recognition features., Houdusse A, Gaucher JF, Krementsova E, Mui S, Trybus KM, Cohen C, Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19326-31. Epub 2006 Dec 6. PMID:17151196

Page seeded by OCA on Thu Mar 20 17:34:34 2008

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