2m9a
From Proteopedia
(Difference between revisions)
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| - | + | ==Solution NMR Structure of E3 ubiquitin-protein ligase ZFP91 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR7784A== | |
| - | + | <StructureSection load='2m9a' size='340' side='right' caption='[[2m9a]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | ==Function== | + | <table><tr><td colspan='2'>[[2m9a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M9A FirstGlance]. <br> |
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FKSG11, ZFP91, ZNF757 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m9a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m9a RCSB], [http://www.ebi.ac.uk/pdbsum/2m9a PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
[[http://www.uniprot.org/uniprot/ZFP91_HUMAN ZFP91_HUMAN]] Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.<ref>PMID:12738986</ref> <ref>PMID:20682767</ref> | [[http://www.uniprot.org/uniprot/ZFP91_HUMAN ZFP91_HUMAN]] Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.<ref>PMID:12738986</ref> <ref>PMID:20682767</ref> | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Ubiquitin protein ligase|Ubiquitin protein ligase]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | <references | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Acton, T B | + | [[Category: Acton, T B]] |
| - | [[Category: Everett, J K | + | [[Category: Everett, J K]] |
| - | [[Category: Janjua, H | + | [[Category: Janjua, H]] |
| - | [[Category: Kohan, E | + | [[Category: Kohan, E]] |
| - | [[Category: Montelione, G T | + | [[Category: Montelione, G T]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: Pederson, K | + | [[Category: Pederson, K]] |
| - | [[Category: Prestegard, J H | + | [[Category: Prestegard, J H]] |
| - | [[Category: Shastry, R | + | [[Category: Shastry, R]] |
| - | [[Category: Xiao, R | + | [[Category: Xiao, R]] |
[[Category: C2h2]] | [[Category: C2h2]] | ||
[[Category: Hr7784a]] | [[Category: Hr7784a]] | ||
[[Category: Metal binding protein]] | [[Category: Metal binding protein]] | ||
[[Category: Nesg]] | [[Category: Nesg]] | ||
| - | [[Category: Northeast structural genomics consortium]] | ||
[[Category: Psi-biology]] | [[Category: Psi-biology]] | ||
[[Category: Psi:biology]] | [[Category: Psi:biology]] | ||
Revision as of 07:56, 25 December 2014
Solution NMR Structure of E3 ubiquitin-protein ligase ZFP91 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR7784A
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Categories: Homo sapiens | Acton, T B | Everett, J K | Janjua, H | Kohan, E | Montelione, G T | Structural genomic | Pederson, K | Prestegard, J H | Shastry, R | Xiao, R | C2h2 | Hr7784a | Metal binding protein | Nesg | Psi-biology | Psi:biology
