4ga8

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'''Unreleased structure'''
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{{STRUCTURE_4ga8| PDB=4ga8 | SCENE= }}
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===Human AKR1B10 mutant V301L complexed with NADP+ and sorbinil===
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The entry 4ga8 is ON HOLD until Aug 01 2014
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==Function==
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[[http://www.uniprot.org/uniprot/AK1BA_HUMAN AK1BA_HUMAN]] Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.<ref>PMID:18087047</ref>
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Authors: Cousido-Siah, A., Ruiz Figueras, F.X., Mitschler, A., Podjarny, A.
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==About this Structure==
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[[4ga8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GA8 OCA].
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Description: Human AKR1B10 mutant V301L complexed with NADP+ and sorbinil
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Cousido-Siah, A.]]
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[[Category: Figueras, F X.Ruiz.]]
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[[Category: Mitschler, A.]]
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[[Category: Podjarny, A.]]
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[[Category: Aldo-keto reductase]]
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[[Category: Oxidoreductase]]
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[[Category: Tim barrel]]

Revision as of 21:01, 7 August 2013

Template:STRUCTURE 4ga8

Contents

Human AKR1B10 mutant V301L complexed with NADP+ and sorbinil

Function

[AK1BA_HUMAN] Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.[1]

About this Structure

4ga8 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Gallego O, Ruiz FX, Ardevol A, Dominguez M, Alvarez R, de Lera AR, Rovira C, Farres J, Fita I, Pares X. Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10. Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20764-9. Epub 2007 Dec 17. PMID:18087047

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OCA

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