4lg9

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'''Unreleased structure'''
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{{STRUCTURE_4lg9| PDB=4lg9 | SCENE= }}
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===Crystal structure of TBL1XR1 WD40 repeats===
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The entry 4lg9 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/TBL1R_HUMAN TBL1R_HUMAN]] F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.<ref>PMID:14980219</ref>
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Authors: Xu, C., Tempel, W., He, H., Wu, X., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
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==About this Structure==
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[[4lg9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LG9 OCA].
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Description: Crystal structure of TBL1XR1 WD40 repeats
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Arrowsmith, C H.]]
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[[Category: Bountra, C.]]
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[[Category: Edwards, A M.]]
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[[Category: He, H.]]
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[[Category: Min, J.]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Tempel, W.]]
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[[Category: Wu, X.]]
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[[Category: Xu, C.]]
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[[Category: Sgc]]
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[[Category: Structural genomics consortium]]
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[[Category: Unknown function]]
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[[Category: Wd40 repeat]]

Revision as of 10:02, 16 April 2014

Template:STRUCTURE 4lg9

Contents

Crystal structure of TBL1XR1 WD40 repeats

Function

[TBL1R_HUMAN] F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.[1]

About this Structure

4lg9 is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Perissi V, Aggarwal A, Glass CK, Rose DW, Rosenfeld MG. A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors. Cell. 2004 Feb 20;116(4):511-26. PMID:14980219

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OCA

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