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4k1g
From Proteopedia
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{{STRUCTURE_4k1g| PDB=4k1g | SCENE= }} | {{STRUCTURE_4k1g| PDB=4k1g | SCENE= }} | ||
===Structure of E. coli Nfo(Endo IV)-H69A mutant bound to a cleaved DNA duplex containing a alphadA:T basepair=== | ===Structure of E. coli Nfo(Endo IV)-H69A mutant bound to a cleaved DNA duplex containing a alphadA:T basepair=== | ||
| + | {{ABSTRACT_PUBMED_23898172}} | ||
==Function== | ==Function== | ||
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==About this Structure== | ==About this Structure== | ||
| - | [[4k1g]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[4k1g]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K1G OCA]. |
| - | [[Category: | + | |
| + | ==See Also== | ||
| + | *[[Endonuclease|Endonuclease]] | ||
| + | |||
| + | ==Reference== | ||
| + | <ref group="xtra">PMID:023898172</ref><references group="xtra"/><references/> | ||
| + | [[Category: Ecoli]] | ||
[[Category: Morera, S.]] | [[Category: Morera, S.]] | ||
[[Category: Vigouroux, A.]] | [[Category: Vigouroux, A.]] | ||
[[Category: Dna endonuclease iv]] | [[Category: Dna endonuclease iv]] | ||
[[Category: Hydrolase-dna complex]] | [[Category: Hydrolase-dna complex]] | ||
Revision as of 13:42, 12 March 2014
Contents |
Structure of E. coli Nfo(Endo IV)-H69A mutant bound to a cleaved DNA duplex containing a alphadA:T basepair
Template:ABSTRACT PUBMED 23898172
Function
[END4_ECOLI] Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin.
About this Structure
4k1g is a 8 chain structure with sequence from Ecoli. Full crystallographic information is available from OCA.
See Also
Reference
- Mazouzi A, Vigouroux A, Aikeshev B, Brooks PJ, Saparbaev MK, Morera S, Ishchenko AA. Insight into mechanisms of 3'-5' exonuclease activity and removal of bulky 8,5'-cyclopurine adducts by apurinic/apyrimidinic endonucleases. Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):E3071-80. doi:, 10.1073/pnas.1305281110. Epub 2013 Jul 29. PMID:23898172 doi:http://dx.doi.org/10.1073/pnas.1305281110
