4k1g

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{{STRUCTURE_4k1g| PDB=4k1g | SCENE= }}
{{STRUCTURE_4k1g| PDB=4k1g | SCENE= }}
===Structure of E. coli Nfo(Endo IV)-H69A mutant bound to a cleaved DNA duplex containing a alphadA:T basepair===
===Structure of E. coli Nfo(Endo IV)-H69A mutant bound to a cleaved DNA duplex containing a alphadA:T basepair===
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{{ABSTRACT_PUBMED_23898172}}
==Function==
==Function==
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==About this Structure==
==About this Structure==
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[[4k1g]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K1G OCA].
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[[4k1g]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K1G OCA].
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[[Category: Escherichia coli k-12]]
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==See Also==
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*[[Endonuclease|Endonuclease]]
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==Reference==
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<ref group="xtra">PMID:023898172</ref><references group="xtra"/><references/>
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[[Category: Ecoli]]
[[Category: Morera, S.]]
[[Category: Morera, S.]]
[[Category: Vigouroux, A.]]
[[Category: Vigouroux, A.]]
[[Category: Dna endonuclease iv]]
[[Category: Dna endonuclease iv]]
[[Category: Hydrolase-dna complex]]
[[Category: Hydrolase-dna complex]]

Revision as of 13:42, 12 March 2014

Template:STRUCTURE 4k1g

Contents

Structure of E. coli Nfo(Endo IV)-H69A mutant bound to a cleaved DNA duplex containing a alphadA:T basepair

Template:ABSTRACT PUBMED 23898172

Function

[END4_ECOLI] Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin.

About this Structure

4k1g is a 8 chain structure with sequence from Ecoli. Full crystallographic information is available from OCA.

See Also

Reference

  • Mazouzi A, Vigouroux A, Aikeshev B, Brooks PJ, Saparbaev MK, Morera S, Ishchenko AA. Insight into mechanisms of 3'-5' exonuclease activity and removal of bulky 8,5'-cyclopurine adducts by apurinic/apyrimidinic endonucleases. Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):E3071-80. doi:, 10.1073/pnas.1305281110. Epub 2013 Jul 29. PMID:23898172 doi:http://dx.doi.org/10.1073/pnas.1305281110

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