4kcc
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
{{STRUCTURE_4kcc| PDB=4kcc | SCENE= }} | {{STRUCTURE_4kcc| PDB=4kcc | SCENE= }} | ||
===Crystal Structure of the NMDA Receptor GluN1 Ligand Binding Domain Apo State=== | ===Crystal Structure of the NMDA Receptor GluN1 Ligand Binding Domain Apo State=== | ||
| + | {{ABSTRACT_PUBMED_23972471}} | ||
==Function== | ==Function== | ||
| Line 9: | Line 10: | ||
==Reference== | ==Reference== | ||
| - | <references group="xtra"/><references/> | + | <ref group="xtra">PMID:023972471</ref><references group="xtra"/><references/> |
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Berger, A J.]] | [[Category: Berger, A J.]] | ||
Revision as of 06:13, 6 November 2013
Contents |
Crystal Structure of the NMDA Receptor GluN1 Ligand Binding Domain Apo State
Template:ABSTRACT PUBMED 23972471
Function
[NMDZ1_RAT] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.[1]
About this Structure
4kcc is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
- Yao Y, Belcher J, Berger AJ, Mayer ML, Lau AY. Conformational Analysis of NMDA Receptor GluN1, GluN2, and GluN3 Ligand-Binding Domains Reveals Subtype-Specific Characteristics. Structure. 2013 Oct 8;21(10):1788-99. doi: 10.1016/j.str.2013.07.011. Epub 2013, Aug 22. PMID:23972471 doi:http://dx.doi.org/10.1016/j.str.2013.07.011
- ↑ Inanobe A, Furukawa H, Gouaux E. Mechanism of partial agonist action at the NR1 subunit of NMDA receptors. Neuron. 2005 Jul 7;47(1):71-84. PMID:15996549 doi:10.1016/j.neuron.2005.05.022
