4by6

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'''Unreleased structure'''
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{{STRUCTURE_4by6| PDB=4by6 | SCENE= }}
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===Yeast Not1-Not2-Not5 complex===
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The entry 4by6 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/NOT5_YEAST NOT5_YEAST]] Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.<ref>PMID:9463387</ref> [[http://www.uniprot.org/uniprot/NOT2_YEAST NOT2_YEAST]] Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. NOT2 is required for the integrity of the complex. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.<ref>PMID:9463387</ref>
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Authors: Bhaskar, V., Basquin, J., Conti, E.
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==About this Structure==
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[[4by6]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_cen.pk113-7d Saccharomyces cerevisiae cen.pk113-7d] and [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BY6 OCA].
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Description: Yeast Not1-Not2-Not5 complex
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Saccharomyces cerevisiae cen pk113-7d]]
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[[Category: Saccharomyces cerevisiae s288c]]
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[[Category: Basquin, J.]]
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[[Category: Bhaskar, V.]]
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[[Category: Conti, E.]]
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[[Category: Cterminal components of the ccr4_not complex]]
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[[Category: Transcription]]

Revision as of 08:05, 16 October 2013

Template:STRUCTURE 4by6

Contents

Yeast Not1-Not2-Not5 complex

Function

[NOT5_YEAST] Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.[1] [NOT2_YEAST] Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. NOT2 is required for the integrity of the complex. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.[2]

About this Structure

4by6 is a 6 chain structure with sequence from Saccharomyces cerevisiae cen.pk113-7d and Saccharomyces cerevisiae s288c. Full crystallographic information is available from OCA.

Reference

  1. ↑ Liu HY, Badarinarayana V, Audino DC, Rappsilber J, Mann M, Denis CL. The NOT proteins are part of the CCR4 transcriptional complex and affect gene expression both positively and negatively. EMBO J. 1998 Feb 16;17(4):1096-106. PMID:9463387 doi:http://dx.doi.org/10.1093/emboj/17.4.1096
  2. ↑ Liu HY, Badarinarayana V, Audino DC, Rappsilber J, Mann M, Denis CL. The NOT proteins are part of the CCR4 transcriptional complex and affect gene expression both positively and negatively. EMBO J. 1998 Feb 16;17(4):1096-106. PMID:9463387 doi:http://dx.doi.org/10.1093/emboj/17.4.1096

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