4l0r

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'''Unreleased structure'''
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{{STRUCTURE_4l0r| PDB=4l0r | SCENE= }}
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===Crystal structure of FGF2-interacting protein from Homo sapiens. Northeast Structural Genomics Consortium Target HR9027A.===
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The entry 4l0r is ON HOLD
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==Disease==
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[[http://www.uniprot.org/uniprot/CEP57_HUMAN CEP57_HUMAN]] Mosaic variegated aneuploidy syndrome. The disease is caused by mutations affecting the gene represented in this entry.
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Authors: Seetharaman, J., Lew, S., Su, M., Ciccosanti, C., Sahdev, S., Acton, T.B., Xiao, R., Everett, J.K., Montelione, G.T., Hunt, J.F., Tong, L., Northeast Structural Genomics Consortium (NESG)
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==Function==
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[[http://www.uniprot.org/uniprot/CEP57_HUMAN CEP57_HUMAN]] Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1.<ref>PMID:22321063</ref>
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Description: Crystal structure of FGF2-interacting protein from Homo sapiens. Northeast Structural Genomics consortium id HR9027A
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==About this Structure==
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[[4l0r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L0R OCA].
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Acton, T B.]]
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[[Category: Ciccosanti, C.]]
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[[Category: Everett, J K.]]
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[[Category: Hunt, J F.]]
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[[Category: Lew, S.]]
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[[Category: Montelione, G T.]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Sahdev, S.]]
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[[Category: Seetharaman, J.]]
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[[Category: Su, M.]]
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[[Category: Tong, L.]]
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[[Category: Xiao, R.]]
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[[Category: Cell cycle]]
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[[Category: Centrosomal protein]]
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[[Category: Cep57]]
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[[Category: Nesg]]
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[[Category: Northeast structural genomics consortium]]
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[[Category: Psi-biology]]
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[[Category: Structural genomic]]

Revision as of 11:00, 4 September 2013

Template:STRUCTURE 4l0r

Contents

Crystal structure of FGF2-interacting protein from Homo sapiens. Northeast Structural Genomics Consortium Target HR9027A.

Disease

[CEP57_HUMAN] Mosaic variegated aneuploidy syndrome. The disease is caused by mutations affecting the gene represented in this entry.

Function

[CEP57_HUMAN] Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1.[1]

About this Structure

4l0r is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Zhen Y, Sorensen V, Skjerpen CS, Haugsten EM, Jin Y, Walchli S, Olsnes S, Wiedlocha A. Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnalpha1 and Kpnbeta1. Traffic. 2012 May;13(5):650-64. doi: 10.1111/j.1600-0854.2012.01341.x. Epub 2012 , Mar 4. PMID:22321063 doi:10.1111/j.1600-0854.2012.01341.x

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OCA

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