4l7d

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'''Unreleased structure'''
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{{STRUCTURE_4l7d| PDB=4l7d | SCENE= }}
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===Structure of keap1 kelch domain with (1S,2R)-2-{[(1S)-5-methyl-1-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}cyclohexanecarboxylic acid===
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{{ABSTRACT_PUBMED_24504667}}
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The entry 4l7d is ON HOLD until Paper Publication
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==About this Structure==
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[[4l7d]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L7D OCA].
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Authors: Jnoff, E., Brookfield, F., Albrecht, C., Barker, J.J., Barker, O., Beaumont, E., Bromidge, S., Brooks, M., Ceska, T., Courade, J.P., Crabbe, T., Duclos, S., Fryatt, T., Jigorel, E., Kwong, J., Sands, Z., Smith, M.A.
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==Reference==
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<ref group="xtra">PMID:024504667</ref><references group="xtra"/><references/>
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Description: Structure of keap1 kelch domain with (1S,2R)-2-{[(1S)-5-methyl-1-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}cyclohexanecarboxylic acid
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[[Category: Albrecht, C.]]
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[[Category: Barker, J J.]]
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[[Category: Barker, O.]]
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[[Category: Beaumont, E.]]
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[[Category: Bromidge, S.]]
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[[Category: Brookfield, F.]]
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[[Category: Brooks, M.]]
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[[Category: Ceska, T.]]
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[[Category: Courade, J P.]]
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[[Category: Crabbe, T.]]
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[[Category: Duclos, S.]]
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[[Category: Fryatt, T.]]
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[[Category: Jigorel, E.]]
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[[Category: Jnoff, E.]]
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[[Category: Kwong, J.]]
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[[Category: Sands, Z.]]
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[[Category: Smith, M A.]]
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[[Category: Beta-propeller]]
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[[Category: Kelch domain]]
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[[Category: Kelch repeat motif]]
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[[Category: Nrf2]]
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[[Category: Protein-small molecule complex]]
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[[Category: Stress sensor]]
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[[Category: Transcription-inhibitor complex]]

Revision as of 17:30, 19 February 2014

Template:STRUCTURE 4l7d

Structure of keap1 kelch domain with (1S,2R)-2-{[(1S)-5-methyl-1-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}cyclohexanecarboxylic acid

Template:ABSTRACT PUBMED 24504667

About this Structure

4l7d is a 3 chain structure. Full crystallographic information is available from OCA.

Reference

  • Jnoff E, Albrecht C, Barker JJ, Barker O, Beaumont E, Bromidge S, Brookfield F, Brooks M, Bubert C, Ceska T, Corden V, Dawson G, Duclos S, Fryatt T, Genicot C, Jigorel E, Kwong J, Maghames R, Mushi I, Pike R, Sands ZA, Smith MA, Stimson CC, Courade JP. Binding Mode and Structure-Activity Relationships around Direct Inhibitors of the Nrf2-Keap1 Complex. ChemMedChem. 2014 Feb 6. doi: 10.1002/cmdc.201300525. PMID:24504667 doi:http://dx.doi.org/10.1002/cmdc.201300525

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OCA

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