4lrs
From Proteopedia
(Difference between revisions)
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| - | + | {{STRUCTURE_4lrs| PDB=4lrs | SCENE= }} | |
| + | ===Crystal and solution structures of the bifunctional enzyme (Aldolase/Aldehyde dehydrogenase) from Thermomonospora curvata, reveal a cofactor-binding domain motion during NAD+ and CoA accommodation whithin the shared cofactor-binding site=== | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/D1A3K8_THECD D1A3K8_THECD]] Catalyzes the retro-aldol cleavage of 4-hydroxy-2-oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity).[HAMAP-Rule:MF_01656] [[http://www.uniprot.org/uniprot/D1A3K7_THECD D1A3K7_THECD]] Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity).[HAMAP-Rule:MF_01657] | ||
| - | + | ==About this Structure== | |
| - | + | [[4lrs]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermomonospora_curvata Thermomonospora curvata] and [http://en.wikipedia.org/wiki/Thermomonospora_curvata_dsm_43183 Thermomonospora curvata dsm 43183]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LRS OCA]. | |
| - | + | [[Category: 4-hydroxy-2-oxovalerate aldolase]] | |
| + | [[Category: Thermomonospora curvata]] | ||
| + | [[Category: Thermomonospora curvata dsm 43183]] | ||
| + | [[Category: Branlant, G.]] | ||
| + | [[Category: Fischer, B.]] | ||
| + | [[Category: Gruez, A.]] | ||
| + | [[Category: Talfournier, F.]] | ||
| + | [[Category: Aldolase]] | ||
| + | [[Category: Dehydrogenase]] | ||
| + | [[Category: Oxidoreductase]] | ||
| + | [[Category: Rossmann fold]] | ||
| + | [[Category: Tim barrel domain]] | ||
Revision as of 11:01, 4 September 2013
Crystal and solution structures of the bifunctional enzyme (Aldolase/Aldehyde dehydrogenase) from Thermomonospora curvata, reveal a cofactor-binding domain motion during NAD+ and CoA accommodation whithin the shared cofactor-binding site
Function
[D1A3K8_THECD] Catalyzes the retro-aldol cleavage of 4-hydroxy-2-oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity).[HAMAP-Rule:MF_01656] [D1A3K7_THECD] Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity).[HAMAP-Rule:MF_01657]
About this Structure
4lrs is a 3 chain structure with sequence from Thermomonospora curvata and Thermomonospora curvata dsm 43183. Full crystallographic information is available from OCA.
