4lwd

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m (Protected "4lwd" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4lwd| PDB=4lwd | SCENE= }}
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===Human CARMA1 CARD domain===
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{{ABSTRACT_PUBMED_24074955}}
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The entry 4lwd is ON HOLD
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==Disease==
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[[http://www.uniprot.org/uniprot/CAR11_HUMAN CAR11_HUMAN]] Persistent polyclonal B-cell lymphocytosis. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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Authors: Zheng, C., Wu, H.
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==Function==
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[[http://www.uniprot.org/uniprot/CAR11_HUMAN CAR11_HUMAN]] Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.
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Description: Human CARMA1 CARD domain
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==About this Structure==
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[[4lwd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LWD OCA].
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==Reference==
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<ref group="xtra">PMID:024074955</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Wu, H.]]
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[[Category: Zheng, C.]]
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[[Category: Bcl10]]
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[[Category: Death domain]]
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[[Category: Signaling protein]]

Revision as of 08:01, 16 October 2013

Template:STRUCTURE 4lwd

Contents

Human CARMA1 CARD domain

Template:ABSTRACT PUBMED 24074955

Disease

[CAR11_HUMAN] Persistent polyclonal B-cell lymphocytosis. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.

Function

[CAR11_HUMAN] Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.

About this Structure

4lwd is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Qiao Q, Yang C, Zheng C, Fontan L, David L, Yu X, Bracken C, Rosen M, Melnick A, Egelman EH, Wu H. Structural Architecture of the CARMA1/Bcl10/MALT1 Signalosome: Nucleation-Induced Filamentous Assembly. Mol Cell. 2013 Sep 26;51(6):766-79. doi: 10.1016/j.molcel.2013.08.032. PMID:24074955 doi:http://dx.doi.org/10.1016/j.molcel.2013.08.032

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OCA

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