4km6
From Proteopedia
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{{STRUCTURE_4km6| PDB=4km6 | SCENE= }} | {{STRUCTURE_4km6| PDB=4km6 | SCENE= }} | ||
===Human folate receptor alpha (FOLR1) at acidic pH, orthorhombic form=== | ===Human folate receptor alpha (FOLR1) at acidic pH, orthorhombic form=== | ||
| + | {{ABSTRACT_PUBMED_23934049}} | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
[[4km6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KM6 OCA]. | [[4km6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KM6 OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:023934049</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: III, C E.Dann.]] | [[Category: III, C E.Dann.]] | ||
Revision as of 05:52, 2 October 2013
Contents |
Human folate receptor alpha (FOLR1) at acidic pH, orthorhombic form
Template:ABSTRACT PUBMED 23934049
Disease
[FOLR1_HUMAN] Neurodegenerative syndrome due to cerebral folate transport deficiency. Neurodegeneration due to cerebral folate transport deficiency (NCFTD) [MIM:613068]: A neurodegenerative disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy and leukodystrophy. Note=The disease is caused by mutations affecting the gene represented in this entry.
Function
[FOLR1_HUMAN] Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.
About this Structure
4km6 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Wibowo AS, Singh M, Reeder KM, Carter JJ, Kovach AR, Meng W, Ratnam M, Zhang F, Dann CE 3rd. Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition. Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15180-8. doi:, 10.1073/pnas.1308827110. Epub 2013 Aug 9. PMID:23934049 doi:10.1073/pnas.1308827110
